The effect of exercise-linked fibronectin type III domain-containing protein 5 (FNDC5)/irisin on synaptic plasticity and memory defects in Alzheimer’s animal models

Leo Sher, M.D. A research report, “Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models” is published in the January 2019 issue of Nature Medicine (1). Irisin is a myokine released into the circulation during physical exercise and is capable of stimulating adipocyte browning and thermogenesis in mice and humans. Irisin is cleaved […]

Limit your anxiety about treating old folks with anxiety

Raymond Pary, M.D., Simrat Kaur Sarai, M.D., Steven Lippmann, M.D. CLINICAL Generalized anxiety disorder (GAD) is characterized by persistent, excessive worry. To confirm a GAD diagnosis, it must persist for over half a year, be present much of the time, and on most days. Those affected frequently express concern about apprehensiveness and/or irritability. Anxious elderly […]

Interview with Professor Shih-Ku Lin

Leo Sher, M.D. Today, we publish an interview with an eminent psychiatrist, Dr. Shih-Ku Lin. Shih-Ku Lin, M.D. is Chair, Department of Psychiatry, Taipei City Hospital and Psychiatric Center, and Professor of Psychiatry, Taipei Medical University, in Taipei, Taiwan. Dr. Lin is also a Vice-President of the International College of Neuropsychopharmacology (CINP) and a Member […]

Prolactin response to fenfluramine administration in patients with mood disorders

Leo Sher, M.D. Fifteen years ago, our paper, “Prolactin response to fenfluramine administration in patients with unipolar and bipolar depression and healthy controls” was published in Psychoneuroendocrinology (1). In this study, we compared the prolactin response to fenfluramine administration in unipolar depressed patients (major depressive disorder), depressed patients with bipolar disorder, and healthy controls. One […]

Gut permeability markers in depression and suicidal behavior

Leo Sher, M.D. A research article, “Leaky gut biomarkers in depression and suicidal behavior” has recently been published in Acta Psychiatrica Scandinavica online ahead of print (1). Researchers examined plasma levels of gut permeability markers in patients with a recent suicide attempt, major depressive disorder (MDD) subjects with no history of a suicide attempt, and […]

Interview with Professor Masahito Fushimi

Leo Sher, M.D. Today, we publish an interview with an eminent psychiatrist, Dr. Masahito Fushimi. Masahito Fushimi, M.D., Ph.D. is the Director of the Akita University Health Center in Akita, Japan, where he is also a Professor. Dr. Fushimi is also a Member of the Japanese Society of Psychiatry and Neurology and a Member of […]

Religiosity, suicidal ideation and suicide attempt

Leo Sher, M.D. A research report, “The association of religiosity with suicidal ideation and suicide attempts in the United Kingdom” has recently been published in Acta Psychiatrica Scandinavica online ahead of print (1). The authors used cross‐sectional data from 7403 people who participated in the 2007 Adult Psychiatric Morbidity Survey (APMS). The association between religiosity […]

The ratio for attempted to completed suicide rates (AS/CS index)

Hilario Blasco-Fontecilla, M.D., Ph.D., Paula Artieda-Urrutia, M.D., Ph.D., Jose de Leon, M.D. Our research article, “A proposal for using the ratio of attempted to completed suicides across several countries worldwide” has recently been published in Epidemiology and Psychiatric Sciences online ahead of print (1). The rates of completed suicide (CS) are available for most developed countries worldwide. […]

Financial hardship in organ donation

Jacob M. Appel, M.D., J.D., M.P.H. Hedda Martin, a sixty-year-old Michigan woman, has attracted national attention after posting online that her healthcare provider urged her to raise $10,000 on GoFundMe, a popular online fundraising platform, in order to be eligible for a life-saving heart transplant.  Martin, a former dog walker and pet sitter, suffered doxorubicin-induced […]

Cerebrospinal fluid homovanillic acid levels in depressed patients with or without a history of alcoholism and healthy controls

Leo Sher, M.D. Fifteen years ago, our paper, “Lower CSF homovanillic acid levels in depressed patients with a history of alcoholism” was published in Neuropsychopharmacology (1). We compared clinical features and cerebrospinal fluid (CSF) monoamine metabolites in depressed subjects with or without a history of alcoholism and healthy volunteers. Sixty-three patients with a current major […]

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