Leo Sher, M.D. A research paper, “Divalproex and its effect on suicide risk in bipolar disorder: A systematic review and meta-analysis of multinational observational studies” has recently been published in the Journal of Affective Disorders (1). In general, studies on the effect of divalproex on suicide risk in patients with bipolar disorder have produced conflicting […]
Leo Sher, M.D. Three days ago, a research report, “Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500000 men and women in China” was published in The Lancet online ahead of print (1). Using data from a nationwide prospective study in China, researchers investigated the relationships between alcohol and […]
Leo Sher, M.D. A web journal, “Expertscape” published a list of top world experts in the field of posttraumatic stress disorder (PTSD) (1). The list is based on 16,933 articles published since 2008. According to “Expertscape” the 10 leading world experts in PTSD are: Richard A. Bryant (Australia) Kerry J. Ressler (USA) Murray B. Stein […]
Leo Sher, M.D. A research report, “Cognitive and emotional impairments underpinning suicidal activity in patients with mood disorders: An fMRI study” has been published in Acta Psychiatrica Scandinavica online ahead of print (1). The authors sought to determine the nature of neural responses to an emotional-cognitive task in patients with suicidal activity. The Columbia Suicide […]
Leo Sher, M.D. On March 5, 2019, the U.S. Food and Drug Administration (FDA) approved Spravato (esketamine) nasal spray, in conjunction with an oral antidepressant, for the treatment of depression in adults who have tried other antidepressant medications but did not improve. Because of the risk of serious side effects related to sedation and dissociation […]
Dilip KC, M.D., Steven Lippmann, M.D. We all know that lithium has important pharmacological properties (1). Most famously, it can provide mood stabilization in patients with bipolar disorders (2). Lithium reduces the risk of suicide in individuals with depression (3). Indeed, it may be helpful in mitigating depressions and possibly in other psychiatric disorders. It […]
Leo Sher, M.D. A research report, “The effects of dietary improvement on symptoms of depression and anxiety: a meta-analysis of randomized controlled trials” has been published in Psychosomatic Medicine online ahead of print (1). The authors conducted a systematic review and meta-analysis examining effects of dietary interventions on symptoms of depression and anxiety. Twenty-six papers […]
Leo Sher, M.D. A research paper, “Patterns of altered regional brain glucose metabolism in borderline personality disorder and bipolar II disorder” has been published in Acta Psychiatrica Scandinavica online ahead of print (1). The authors examined brain glucose metabolism in patients with borderline personality disorder, in patients with bipolar II disorder, and healthy controls. In […]
Leo Sher, M.D. Our research report, “Moral objections to suicide and suicidal ideation among mood disordered Whites, Blacks, and Hispanics” was published in the January 2009 issue of the Journal of Psychiatric Research (1). We examined the moral objections to suicide and suicidal ideation of White, Black, and Hispanic individuals with mood disorders. In all, […]
Leo Sher, M.D. A research report, “Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models” is published in the January 2019 issue of Nature Medicine (1). Irisin is a myokine released into the circulation during physical exercise and is capable of stimulating adipocyte browning and thermogenesis in mice and humans. Irisin is cleaved […]
