An examination of serotonin function in depressed patients with or without a history of alcohol use disorders and healthy controls

Leo Sher, M.D. Our research work, “Serotonergic responses in depressed patients with or without a history of alcohol use disorders and healthy controls” was published 15 years ago, in the September 2008 issue of European Neuropsychopharmacology (1). To compare serotonin function in major depressive disorder with co-occurring alcohol use disorder, major depressive disorder without co-occurring […]

CSF HVA concentrations in depressed individuals with or without a history of alcoholism and healthy controls

Leo Sher, M.D. Our research paper, “Lower CSF homovanillic acid levels in depressed patients with a history of alcoholism” was published 20 years ago, in the September 2003 issue of Neuropsychopharmacology (1). We compared clinical features and cerebrospinal fluid (CSF) monoamine metabolites in depressed subjects with or without a history of alcoholism and healthy volunteers. […]

Navigating ethical dilemmas in genetic testing for Huntington’s Disease

Rana Anwar, M.D., Steven Lippmann, M.D. Introduction: Genetic testing for Huntington’s Disease (HD) offers a precise diagnosis but raises many questions. These include privacy concerns to complex family dynamics; the impact of HD testing extends beyond individual choices. There are clinical dilemmas surrounding HD genetic testing that require thoughtful consideration. Discrimination /Privacy: One of the […]

Loneliness: Surgeon General Dr. Murthy’s warning

Amrit Kahlon, M.D., Adil Khan, M.D., Steven Lippmann, M.D.                                                                                             […]

Age and antisuicidal effect of lithium

Leo Sher, M.D. Our research work, “Antisuicidal effect of lithium in bipolar patients: Is there an age-specific effect?” has been published in the Journal of Affective Disorders online ahead of print (1). The age-related antisuicidal effect of lithium and valproate was compared in ninety-four (n = 94) high-risk bipolar suicide attempters. Individuals with bipolar disorder […]

Suicide rates in the United States in 2022

Leo Sher, M.D. Three days ago, U.S. Centers for Disease Control and Prevention (CDC) released provisional data on suicide rates in the U.S. in 2022 (1).  More people died by suicide in the U.S. in 2022 than any other year on record. Overall, 49,449 Americans (39,255 men and 10,194 women) died by suicide in 2022, […]

Intranasal esketamine ought to be more widely available

Steven Lippmann, M.D. There are concerns nation-wide about not having the latest interventional psychiatric treatment options available for clinical prescribing. For just one single example, intranasal esketamine is not uniformly present in some healthcare formularies. There are instances where financial, clinical, and/or other administrative hurdles block this new pharmacotherapy even to hospital emergency medicine departments. […]

Obesity is associated with increased risk for psychiatric disorders

Leo Sher, M.D. A research report, “Obesity as pleiotropic risk state for metabolic and mental health throughout life” has recently been published in Translational Psychiatry (1). A significant part of the worldwide population is overweight. Obesity is a substantial global health burden. The prevalence rates of obesity have been progressively increasing over the past decades. […]

DHEA and DHEAS blood levels in combat veterans with or without a history of suicide attempt

Leo Sher, M.D. Our research work, “Dehydroepiandrosterone and dehydroepiandrosterone sulfate levels in combat veterans with or without a history of suicide attempt” was published 5 years ago, in the July 2018 issue of Acta Psychiatrica Scandinavica (1). Demographic and clinical parameters of combat veterans who have made a suicide attempt postdeployment and combat veterans who […]

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