Combined dexamethasone suppression-corticotrophin-releasing hormone stimulation test in medication-free individuals with major depression and healthy controls

Leo Sher, M.D. Our research report, “Combined dexamethasone suppression-corticotrophin-releasing hormone stimulation test in medication-free major depression and healthy volunteers” was published 10 years ago in the December 2013 issue of the Journal of Affective Disorders (1). A combined dexamethasone suppression– corticotrophin-releasing hormone stimulation (DEX–CRH) test has been developed as a potentially sensitive measure of hypothalamic–pituitary–adrenal […]

Suicide in combat veterans

Leo Sher, M.D. My article, “The uncounted casualties of war: suicide in combat veterans” was published in the QJM: An International Journal of Medicine online ahead of print on October 17, 2023 (1). A summary of my article is below: Military conflicts are ubiquitous. There are a lot of combat veterans around the world. Suicidality […]

An examination of serotonin function in depressed patients with or without a history of alcohol use disorders and healthy controls

Leo Sher, M.D. Our research work, “Serotonergic responses in depressed patients with or without a history of alcohol use disorders and healthy controls” was published 15 years ago, in the September 2008 issue of European Neuropsychopharmacology (1). To compare serotonin function in major depressive disorder with co-occurring alcohol use disorder, major depressive disorder without co-occurring […]

CSF HVA concentrations in depressed individuals with or without a history of alcoholism and healthy controls

Leo Sher, M.D. Our research paper, “Lower CSF homovanillic acid levels in depressed patients with a history of alcoholism” was published 20 years ago, in the September 2003 issue of Neuropsychopharmacology (1). We compared clinical features and cerebrospinal fluid (CSF) monoamine metabolites in depressed subjects with or without a history of alcoholism and healthy volunteers. […]

Navigating ethical dilemmas in genetic testing for Huntington’s Disease

Rana Anwar, M.D., Steven Lippmann, M.D. Introduction: Genetic testing for Huntington’s Disease (HD) offers a precise diagnosis but raises many questions. These include privacy concerns to complex family dynamics; the impact of HD testing extends beyond individual choices. There are clinical dilemmas surrounding HD genetic testing that require thoughtful consideration. Discrimination /Privacy: One of the […]

Loneliness: Surgeon General Dr. Murthy’s warning

Amrit Kahlon, M.D., Adil Khan, M.D., Steven Lippmann, M.D.                                                                                             […]

Age and antisuicidal effect of lithium

Leo Sher, M.D. Our research work, “Antisuicidal effect of lithium in bipolar patients: Is there an age-specific effect?” has been published in the Journal of Affective Disorders online ahead of print (1). The age-related antisuicidal effect of lithium and valproate was compared in ninety-four (n = 94) high-risk bipolar suicide attempters. Individuals with bipolar disorder […]

Suicide rates in the United States in 2022

Leo Sher, M.D. Three days ago, U.S. Centers for Disease Control and Prevention (CDC) released provisional data on suicide rates in the U.S. in 2022 (1).  More people died by suicide in the U.S. in 2022 than any other year on record. Overall, 49,449 Americans (39,255 men and 10,194 women) died by suicide in 2022, […]

Intranasal esketamine ought to be more widely available

Steven Lippmann, M.D. There are concerns nation-wide about not having the latest interventional psychiatric treatment options available for clinical prescribing. For just one single example, intranasal esketamine is not uniformly present in some healthcare formularies. There are instances where financial, clinical, and/or other administrative hurdles block this new pharmacotherapy even to hospital emergency medicine departments. […]

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