Suicidal ideation in depressed patients with or without comorbid posttraumatic stress disorder treated with selective serotonin reuptake inhibitors

Leo Sher, M.D. Our research report, “Decreased suicidal ideation in depressed patients with or without comorbid posttraumatic stress disorder treated with selective serotonin reuptake inhibitors: an open study” was published 10 years ago in the April 2012 issue of Psychiatry Research (1). We have examined clinical parameters before and after three months of open selective […]

Suicidal behavior in depressed older adolescents and young adults with or without comorbid alcohol use disorder

Leo Sher, M.D. Our research report, “Triggers for suicidal behavior in depressed older adolescents and young adults: do alcohol use disorders make a difference?” was published in the January-March 2007 issue of the International Journal of Adolescent Medicine and Health (1). In this study, we compared demographic and clinical characteristics, prevalence of interpersonal triggers and […]

Suicide mortality in the U.S. decreased from 2018 to 2020 after increasing since 2000

Leo Sher, M.D. The report, “Suicide mortality in the United States, 2000–2020” has recently been published by the U.S. Centers for Disease Control and Prevention National Center for Health Statistics (1). According to this report, suicide mortality in the U.S. increased from 2000 to 2018, then decreased from 2018 to 2020. Suicide deaths were identified […]

Thirty years of publications in the field of suicidology

Leo Sher, M.D. A research report, “Thirty years of publications in suicidology: A bibliometric analysis” has recently been published in Archives of Suicide Research (1). The authors performed a quantitative assessment of publications in suicidology between 1989 and 2018. Web of Science was used to identify publications on suicidal behavior from January 1, 1989 to […]

Osteoporosis drugs are associated with depression and anxiety

Leo Sher, M.D. A research paper, “Common osteoporosis drug associated with increased rates of depression and anxiety” has recently been published in Scientific Reports (1). Amongst the most common drug therapies for osteoporosis are bisphosphonates, including alendronate, zoledronate, ibandronate and risedronate. Other first-line options with a different molecular mechanism include denosumab and teriparatide. The author […]

Smoking, suicide risk, and the COVID-19 pandemic

Leo Sher, M.D. My commentary, “Smoking enhances suicide risk-a significant role in the COVID-19 pandemic?” has recently been published in the QJM: An International Journal of Medicine (1). A summary of my article is below: The COVID-19 outbreak has severely affected the whole world. Considerable evidence suggests that tobacco smoking is associated with increased severity […]

Samuel Johnson quote

Nothing will ever be attempted if all possible objections must be first overcome. – Samuel Johnson (1709 -1784)

Cerebrospinal fluid monoamine metabolites and lethality of suicide attempts in depressed patients with alcohol use disorder

Leo Sher, M.D. Our research paper, “CSF monoamine metabolites and lethality of suicide attempts in depressed patients with alcohol dependence” was published 15 years ago in the January 2007 issue of European Neuropsychopharmacology (1). In this study, we investigated the relationship of cerebrospinal fluid (CSF) 5-hydroxyindolacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) levels […]

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