Jaanus Harro, M.D., Ph.D.

Jaanus Harro, M.D., Ph.D.Jaanus Harro, M.D., Ph.D.
Professor of Psychophysiology

Department of Psychology
University of Tartu, Estonia

Jaanus Harro received the degree of Candidate of Medical Sciences in Pharmacology at the University of Tartu in 1990, and Doctor of Medicine in Medical Pharmacology at the University of Uppsala in 1993.

Currently Jaanus Harro is Professor of Psychophysiology at the University of Tartu, and Director of the Estonian Centre of Behavioural and Health Sciences. He has contributed to psychopharmacology of anxiolytic, anxiogenic, and antidepressant drugs and neuropeptides, developed animal models of human psychopathology, and studied molecular genetics of affect in humans. Jaanus Harro has published about 150 papers in major journals and book chapters, and supervised sixteen completed PhD dissertations in medicine, psychology and biochemistry.

Jaanus Harro is member of Collegium Internationale Neuro-Psychopharmacologicum, European College of Neuro-Psychopharmacology and Society for Neuroscience. Currently he serves as a member of the Executive Committee of the ECNP, and is a Field Editor of “European Neuropsychopharmacology”. Jaanus Harro is also a member of the Estonian Society of Pharmacology, the Estonian Union of Psychologists and the Estonian Association of Psychiatrists, also serving as the chairman of the Biological Psychiatry Section of the latter. He has received the National Science Prize in Medicine (2005) and the Order of White Star Class IV.

LIST OF PUBLICATIONS
I
(Book Chapters)

1. J.Harro, M.Põld, E.Vasar, L.Allikmets The role of brain cholecystokinin receptors in generation of anxiety states in mice and rats. In: K.V.Sudakov (Ed.) Systems Research in Physiology, Vol. 5. Gordon & Breach, London (1989) pp. 180-196
2. E.Vasar, J.Harro, A.Põld, A.Lang CCK receptors and anxiety in rats. In: C.T.Dourish, S.J.Cooper, S.D.Iversen, L.L.Iversen (eds) Multiple Cholecystokinin Receptors in the CNS (1992) Oxford University Press, pp. 143-148
3. J.Harro Measurement of Exploratory Behaviour in Rodents. In: P.M.Conn (Ed.) Methods in Neurosciences, Vol. 14, Academic Press, San Diego (1993) pp. 359-377
4. E. Peuranen, A. Lang, J. Harro, E. Vasar, P.T. Männistö Effect of caerulein and cholecystokinin antagonists on hypophyseal hormone secretion in single-housed and group-housed male rats. In: S. Seredenin, V.G. Longo (eds) Biological Basis of Individual Sensitivity to Psychotropic Drugs Harwood Academic Publishers Amsterdam 1994, pp 63-72
5. J. Harro, E. Vasar, D. Koszycki, J. Bradwejn The CCK hypothesis of anxiety and panic. In: J. Panksepp (ed) Advances in Biological Psychiatry, Vol 1, JAI Press 1995, pp 235-262.
6. J. Harro, E. Vasar, L. Oreland, P.T. Männistö Animal studies on CCK and anxiety. In: J. Bradwejn, E. Vasar (eds) CCK and Anxiety: from Neuron to Behaviour. R.G. Landes Company (1995) 57-72
7. M. Sallo, J. Harro, A. Viru Moderate to vigorous physical activities in preadolescent children. In: N. Armstrong, B.J. Kirby, J.R. Welsman (eds) Children and Exercise XIX: Promoting Children’s Health and Well-being. E & FN Spon (Chapman & Hall) London 1997, pp 151-156
8. J. Harro, H. Rimm, M. Sallo, N. Jaanimägi, A. Päevloo, I. Villa Does the personality of parents influence the physical activity of their children? In: N. Armstrong, B.J. Kirby, J.R. Welsman (eds) Children and Exercise XIX: Promoting Children’s Health and Well-being. E & FN Spon (Chapman & Hall) London 1997, pp 157-162
9. L. Oreland, M. Damberg, H. Garpenstrand, J. Harro, J. Hallman Platelet monoamine oxidase, transcription factor AP-2 and personality – a functional triangle? In: T. Nagatsu, T. Nabeshima, R. McCarty, D.S. Goldstein (eds) Catecholamine Research: From Molecular Insights to Clinical Medicine. Kluwer Academic/Plenum Publishers 2002, pp 439-442
10. J. Panksepp, J. Harro Future of neuropeptides in biological psychiatry and emotional psychopharmacology: Goals and strategies. In: J. Panksepp (ed) Textbook of Biological Psychiatry, John Wiley & Sons, 2004, pp 627-659
11. J. Harro Appendix A: Pharmacodynamics and pharmacokinetics. In: J. Panksepp (ed) Textbook of Biological Psychiatry, John Wiley & Sons 2004, pp 661-681
12. J. Harro On Holy Ground: Modern neuropsychopharmacology in the old laboratories of Buchheim, Schmiedeberg and Kraepelin in Tartu/Dorpat. In: T.A. Ban, D. Healy, E. Shorter (eds) Reflections on Twentieth-Century Psychopharmacology. Animula, Budapest 2004, pp 355-360
13. J. Harro Cholecystokinins. In: I.P. Stolerman (ed) Encyclopedia of Psychopharmacology. Springer-Verlag Berlin Heidelberg 2010 (in press)

LIST OF PUBLICATIONS
II
(Original Articles in International Peer-Reviewed Journals)

1. L.K.Rägo, R.A.K.Kiivet, J.E.Harro, L.H.Allikmets Benzodiazepine binding sites in mice forebrain and kidneys: evidence for similar regulation by GABA agonists. Pharmacology Biochemistry & Behavior (1986) 24: 1-3
2. L.Rägo, R.-A.Kiivet, J.Harro Variation in behavioral response to baclofen: correlation with benzodiazepine binding sites in mouse forebrain. Naunyn-Schmiedeberg´s Archives of Pharmacology (1986) 333: 303-306
3. L.Rägo, R.-A.Kiivet, J.Harro, M.Põld Behavioral differences in an elevated plus-maze: correlation between anxiety and decreased number of GABA and benzodiazepine receptors in mouse cerebral cortex. Naunyn-Schmiedeberg´s Archives of Pharmacology (1988) 337: 675-678
4. L.Rägo, R.-A.Kiivet, J.Harro, M.Põld Central- and peripheral-type benzodiazepine receptors: similar regulation by stress and GABA receptor agonists. Pharmacology Biochemistry & Behavior (1989) 32: 879-883
5. J.Harro, M.Põld, E.Vasar, L.Allikmets Participation of CCK-8-ergic mechanisms in the regulation of emotional behaviour in rodents. Zhurnal Vysshey Nervnoy Deyatelnosty (1989) 39: 877-883
6. E.Vasar, A.Lang, J.Harro, L.Allikmets Adaptational changes on sigma and phencyclidine receptors during long-term treatment with haloperidol and raclopride in rats. Bulletin of Experimental Biology and Medicine (1989) 108: 306-309
7. J.Harro, M.Põld, E.Vasar Anxiogenic-like action of caerulein, a CCK-8 receptor agonist, in the mouse: influence of acute and subchronic diazepam treatment. Naunyn-Schmiedeberg’s Archives of Pharmacology (1990) 341: 62-67
8. J.Harro, A.Lang, E.Vasar Long-term diazepam treatment produces changes in cholecystokinin receptor binding in rat brain. European Journal of Pharmacology (1990) 180: 77-83
9. J.Harro, R.-A.Kiivet, A.Lang, E.Vasar Rats with anxious or non-anxious type of exploratory behaviour differ in their brain CCK-8 and benzodiazepine receptor characteristics. Behavioural Brain Research (1990) 39: 63-71
10. V.Klusa, R.-A.Kiivet, R.Muceniece, I.Liepa, J.Harro, S.Svirskis, A.Andermanis, L.Rägo Thymopentin antagonizes stress-induced changes of GABA/benzodiazepine receptor complex. Regulatory Peptides (1990) 27: 355-365
11. L.Rägo, R.-A.Kiivet, A.Adojaan, J.Harro, L.Allikmets Stress-protective action of beta-phenyl(GABA): involvement of central and peripheral type benzodiazepine binding sites. Pharmacology & Toxicology (1990) 66: 41-44
12. J.Harro, E.Vasar Evidence that CCKB receptors mediate the regulation of exploratory behaviour in the rat. European Journal of Pharmacology (1991) 193: 379-381
13. L.Rägo, A.Adojaan, J.Harro, R.-A.Kiivet Correlation between exploratory activity in an elevated plus-maze and number of central and peripheral benzodiazepine binding sites. Naunyn-Schmiedeberg´s Archives of Pharmacology (1991) 343: 301-306
14. E.Vasar, J.Harro, A.Lang, A.Põld, A.Soosaar Differential involvement of CCK-A and CCK-B receptors in the regulation of locomotor activity in the mouse. Psychopharmacology (1991) 105: 393-399
15. J.Harro, E.Vasar Cholecystokinin-induced anxiety: How is it reflected in studies on exploratory behaviour? Neuroscience & Biobehavioral Reviews (1991) 15: 473-477
16. J.Harro, L.Oreland Age-related differences of cholecystokinin receptor binding in the rat brain. Progress in Neuro-Psychopharmacology & Biological Psychiatry (1992) 16: 369-375
17. J.Harro, J.Marcusson, L.Oreland Alterations in brain cholecystokinin receptors in suicide victims. European Neuropsychopharmacology (1992) 2: 57-63
18. J.Harro, S.S.Jossan, L.Oreland Changes in cholecystokinin receptor binding in rat brain after selective damage of locus coeruleus projections by DSP-4 treatment. Naunyn-Schmiedeberg´s Archives of Pharmacology (1992) 346: 425-431
19. E.Vasar, A.Soosaar, J.Harro, A.Lang Changes at cholecystokinin receptors induced by long-term treatment with diazepam and haloperidol. European Neuropsychopharmacology (1992) 2: 447-454
20. A.Lang, E.Vasar, A.Soosaar, J.Harro The involvement of sigma and phencyclidine receptors in the action of antipsychotic drugs. Pharmacology & Toxicology (1992) 71: 132-138
21. P.T.Männistö, E.Peuranen, J.Harro, E.Vasar Possible role of cholecystokinin-A receptors in regulation of thyrotropin (TSH) secretion in male rats. Neuropeptides (1992) 23: 251-258
22. J.Harro, P.Westerling, L.Oreland CCKB receptor activation reduces glutamate-induced depolarization in slices of rat cerebral cortex. Journal of Neural Transmission [General Section] (1993) 93: 61-66
23. J.Harro, L.Oreland Cholecystokinin receptors and memory: A radial maze study. Pharmacology Biochemistry & Behavior (1993) 44: 509-517
24. E.Vasar, E.Peuranen, J.Harro, A.Lang, L.Oreland, P.T.Männistö Social isolation of rats increases the density of cholecystokinin receptors in the frontal cortex and abolishes the anti-exploratory effect of caerulein. Naunyn-Schmiedeberg’s Archives of Pharmacology (1993) 348: 96-101
25. E.Vasar, J.Harro, A.Lang, A.Soosaar, T.Ööpik, S. Kõks, S.Sihver, V.Volke Anti-exploratory effect of N-methyl-D-aspartate in elevated plus-maze. Involvement of NMDA and CCK receptors. European Neuropsychopharmacology (1993) 3: 63-73
26. E.Vasar, E.Peuranen, T.Ööpik, J.Harro, P.T.Männistö Ondansetron, an antagonist of 5-HT3 receptors, antagonizes the anti-exploratory effect of caerulein, an agonist of CCK receptors, in the elevated plus-maze. Psychopharmacology (1993) 110: 213-218
27. J.Harro, E.Vasar, J.Bradwejn Cholecystokinin in animal and human research on anxiety. Trends in Pharmacological Sciences (1993) 14: 244-249
28. J. Harro, G. Wahlström, L. Oreland Cholecystokinin receptor binding after long-term ethanol treatment in rats. Alcohol & Alcoholism (1994) 29: 575-581
29. M. Welin, J. Harro, R. Yukhananov, F. Nyberg, L. Oreland Cholecystokinin receptor binding in morphine analgesia, tolerance, withdrawal and abstinence. Neuropeptides (1994) 26: 379-383
30. F. Sherif, J. Harro, A. El-Hwuegi, L. Oreland Anxiolytic-like effect of the GABA-transaminase inhibitor vigabatrin (gamma-vinyl GABA) on rat exploratory activity. Pharmacology Biochemistry & Behavior (1994) 49: 801-805
31. E. Vasar, A. Lang, J. Harro, M. Bourin, J. Bradwejn Evidence for potentiation by CCK antagonists of the effect of cholecystokinin octapeptide in the elevated plus-maze. Neuropharmacology (1994) 33: 729-735
32. P.T. Männistö, A. Lang, J. Harro, E. Peuranen, J. Bradwejn, E. Vasar Opposite effects mediated by CCKA and CCKB receptors in behavioural and hormonal studies in rats. Naunyn-Schmiedeberg’s Archives of Pharmacology (1994) 349: 478-484
33. E. Vasar, A. Lang, J. Harro, S. Kõks, V. Volke, S. Sihver, M. Bourin, J. Bradwejn, P.T. Männistö Subdiaphragmatic vagotomy does not prevent the anti-exploratory effect of caerulein in the elevated plus-maze. Neuropeptides (1994) 26: 39-45
34. J. Harro, L.Oreland, E. Vasar, J. Bradwejn Impaired exploratory behaviour after DSP-4 treatment in rats: implications for the increased anxiety after noradrenergic denervation. European Neuropsychopharmacology (1995) 5: 447-455
35. A. Lang, J. Harro, A. Soosaar, S. Kõks, V.Volke, L. Oreland, M. Bourin, E. Vasar, J. Bradwejn, P.T. Männistö Role of N-methyl-D-aspartic acid and cholecystokinin receptors in apomorphine-induced aggressive behaviour in rats. Naunyn-Schmiedeberg’s Archives of Pharmacology (1995) 351: 363-370
36. C. Löfberg, J. Harro, C.-G. Gottfries, L. Oreland Cholecystokinin peptides and receptor binding in Alzheimer’s disease. Journal of Neural Transmission [Parkinson’s Disease and Dementia Section] (1996) 103: 851-860
37. J. Harro, C. Löfberg, J. Rehfeld, L. Oreland Cholecystokinin peptides and receptors in the rat brain during stress. Naunyn-Schmiedeberg’s Archives of Pharmacology (1996) 354: 59-66
38. V. Matto, J. Harro, L. Allikmets The effects of cholecystokinin A and B receptor antagonists, devazepide and L 365,260, on citalopram-induced decrease of exploratory behaviour in rat. Journal of Physiology and Pharmacology (1996) 47: 661-669
39. J. Harro, L. Oreland Depression as a spreading neuronal adjustment disorder. European Neuropsychopharmacology (1996) 6: 207-223
40. R. Pähkla, J. Harro, L. Rägo Behavioural effects of pinoline in the rat forced swimming, open field and elevated plus-maze tests. Pharmacological Research (1996) 34: 73-78
41. A. Kask, L. Rägo, J. Harro Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226: antagonism with diazepam. European Journal of Pharmacology (1996) 317: R3-R4
42. J. Harro, C. Löfberg, R. Pähkla, V. Matto, L. Rägo, L. Oreland, L. Allikmets Different molecular forms of cholecystokinin and CCKB receptor binding in the rat brain after chronic antidepressant treatment. Naunyn-Schmiedeberg’s Archives of Pharmacology (1997) 355: 57-63
43. A. Kask, J. Harro, P. Tuomainen, L. Rägo, P.T. Männistö Overflow of noradrenaline and dopamine in frontal cortex in [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine] (DSP-4) treated rats: in vivo microdialysis study. Naunyn-Schmiedeberg’s Archives of Pharmacology (1997) 355: 267-272
44. V. Matto, J. Harro, L. Allikmets The effects of cholecystokinin A and B receptor antagonists on exploratory behaviour in the elevated zero-maze in rat. Neuropharmacology (1997) 36: 389-396
45. V. Matto, J. Harro, L. Allikmets The effect of drugs acting on CCK receptors and rat free exploration in the exploration box. Journal of Physiology and Pharmacology (1997) 48:239-251
46. M.-H. Otter, V. Matto, R. Sõukand, T. Skrebuhhova, L. Allikmets, J. Harro Characterization of rat exploratory behaviour using the exploration box test. Methods and Findings in Experimental and Clinical Pharmacology (1997) 19: 683-691
47. A. Kask, L. Rägo, J. Harro -Helical CRF9-41 prevents anxiogenic-like effect of NPY Y1 receptor antagonist BIBP3226 in rats. Neuroreport (1997) 8: 3645-3647
48. A. Rinken, J. Harro, L. Engström, L. Oreland Role of fluidity of membranes on the guanyl nucleotide-dependent binding of cholecystokinin-8s to rat brain cortical membranes. Biochemical Pharmacology (1998) 55: 423-431
49. C. Löfberg, H. Ågren, J. Harro, L. Oreland Cholecystokinin in the CSF from depressed patients: possible relations to severity of depression and suicidal behaviour. European Neuropsychopharmacology (1998) 8: 153-157
50. A. Kask, L. Rägo, J. Harro Anxiolytic-like effects of NPY and NPY13-36 microinjected into vicinity of locus coeruleus in rats. Brain Research (1998) 788: 345-348
51. C. Löfberg, J. Harro, V. Matto, L. Oreland Cholecystokinin peptides and receptor binding in rat brain after DSP-4 treatment. Neuropeptides (1998) 32: 103-108
52. A. Kask, L. Rägo, J. Harro Anxiogenic-like effect of the NPY Y1 receptor antagonist BIBP3226 administered into the dorsal periaqueductal gray matter in rats. Regulatory Peptides (1998) 7576: 255-262
53. A. Kask, L. Rägo, J. Harro Opposite effects of [Leu31,Pro34]NPY and NPY13-36 on hypnotic response to 2-adrenoceptor agonist dexmedetomidine microinjected into rat locus coeruleus. Neuroscience Research Communications (1998) 23: 41-44
54. A. Kask, L. Rägo, J. Harro Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226. British Journal of Pharmacology (1998) 124: 1507-1515
55. A. Kask, L. Rägo, J. Harro NPY Y1 receptors in the dorsal periaqueductal gray matter regulate anxiety in the social interaction test. Neuroreport (1998) 9: 2713-2716
56. J. Harro, H. Rimm, M. Harro, M. Grauberg, K. Karelson, A.-M. Viru Association of depressiveness with blunted growth hormone response to maximal physical exercise in young healthy men. Psychoneuroendocrinology (1999) 24: 505-517
57. A. Kask, T. Kivastik, L. Rägo, J. Harro Neuropeptide Y Y1 receptor antagonist BIBP3226 produces conditioned place aversion in rats. Progress in Neuro-Psychopharmacology & Biological Psychiatry (1999) 23: 705-711
58. J. Harro, R. Pähkla, A.-R. Modiri, M. Harro, A. Kask, L. Oreland Dose-dependent effects of noradrenergic denervation by DSP-4 treatment on forced swimming and ß-adrenoceptor binding in the rat. Journal of Neural Transmission (1999) 106: 619-629
59. J. Harro, R. Häidkind, M. Harro, A.-R. Modiri, P.-G. Gillberg, R. Pähkla, V. Matto, L. Oreland Chronic mild unpredictable stress after noradrenergic denervation: attenuation of behavioural and biochemical effects of DSP-4 treatment. European Neuropsychopharmacology (1999) 10: 5-16
60. J. Harro, A. Meriküla, M. Lepiku, A.-R. Modiri, A. Rinken, L. Oreland Lesioning of the locus coeruleus projections by DSP-4 treatment: the effect on amphetamine-induced hyperlocomotion and dopamine D2 receptor binding in the rat. Pharmacology & Toxicology (2000) 86: 197-202
61. A. Kask, J. Harro Inhibition of amphetamine and apomorphine-induced behavioural effects by neuropeptide Y Y1 receptor antagonist BIBO 3304. Neuropharmacology (2000) 39: 1292-1302
62. J.A. Prince, J. Harro, K. Blennow, C.G. Gottfries, L. Oreland Putamen mitochondrial energy metabolism is highly correlated to emotional and intellectual impairment in schizophrenics. Neuropsychopharmacology (2000) 22: 284-292
63. A. Kask, H. Schiöth, J. Harro, J. Wikberg, L. Rägo Orexigenic effect of the MC4 antagonist HS014 is only partially inhibited by neuropeptide Y Y1 receptor antagonists. Canadian Journal of Physiology and Pharmacology (2000) 78: 143-149
64. A. Kask, M. Eller, L. Oreland, J. Harro Neuropeptide Y attenuates the effect of locus coeruleus denervation by DSP-4 treatment on social behaviour in the rat. Neuropeptides (2000) 34: 58-61
65. D. Eensoo, J. Harro, M. Harro, H. Rimm, A.-M. Viru Depressiveness, anxiety, perceived stress and self-efficacy in middle-aged men with different engagement in physical activity. Medicina dello Sport (2000) 53: 69-74
66. M. Harro, D. Eensoo, E. Kiive, L. Merenäkk, J. Alep, L. Oreland, J. Harro Platelet monoamine oxidase in healthy 9- and 15-years old children: the effect of gender, smoking and puberty. Progress in Neuro-Psychopharmacology & Biological Psychiatry (2001) 25: 1497-1511
67. J. Harro, A.-M. Viru Endurance training by forced swimming reduces emotionality in rats. Biology of Sport (2001) 18: 119-125
68. J. Harro, M. Tõnissaar, M. Eller, A. Kask, L. Oreland Chronic variable stress and partial 5-HT denervation by parachloroamphetamine treatment in the rat: effects on behavior and monoamine neurochemistry. Brain Research (2001) 899: 227-239
69. J. Harro, M. Tõnissaar, M. Eller The effects of CRA 1000, a non-peptide antagonist of corticotropin-releasing factor receptor type 1, on adaptive behaviour in the rat. Neuropeptides (2001) 35: 100-109
70. M. Damberg, M. Eller, M. Tõnissaar, L. Oreland, J. Harro Levels of transcription factors AP-2 and AP-2ß in the brainstem are correlated to monoamine turnover in the rat forebrain. Neuroscience Letters (2001) 313: 102-104
71. J. Harro, L. Oreland Depression as a spreading adjustment disorder of monoaminergic neurons: a case for primary implication of the locus coeruleus. Brain Research Reviews (2001) 38: 79-128
72. E. Kiive, D. Eensoo, M. Harro, J. Harro Platelet monoamine oxidase activity in association with childhood aggressive and hyperactive behaviour: the effect of smoking? Personality & Individual Differences (2002) 33: 355-363
73. M. Eller, J. Harro Partial denervation of the locus coeruleus projections by treatment with the selective neurotoxin DSP-4 potentiates the long-term effect of parachloroamphetamine on 5-HT metabolism in the rat. Neuroscience Letters (2002) 322: 53-56
74. A. Kask, J. Harro, S. von Hörsten, P. Redrobe, Y. Dumont, R. Quirion The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y. Neuroscience & Biobehavioral Reviews (2002) 26: 259-283
75. R. Häidkind, T. Kivastik, M. Eller, I. Kolts, L. Oreland, J. Harro Denervation of the locus coeruleus projections by treatment with the selective neurotoxin DSP-4 reduces dopamine release potential in the nucleus accumbens shell in conscious rats. Neuroscience Letters (2002) 332: 79-82
76. J. Harro Long-term partial 5-HT depletion: interference of anxiety and impulsivity? Psychopharmacology (2002) 164: 433-434
77. R. Häidkind, M. Eller, M. Harro, A. Kask, A. Rinken, L. Oreland, J. Harro Effects of partial locus coeruleus denervation and chronic mild stress on behaviour and monoamine neurochemistry in the rat. European Neuropsychopharmacology (2003) 13: 19-28
78. L. Merenäkk, M. Harro, E. Kiive, K. Laidra, D. Eensoo, J. Allik, L. Oreland, J. Harro Association between substance use, personality traits and platelet MAO activity in preadolescents and adolescents. Addictive Behaviors (2003) 28: 1507-1514
79. J. Harro, A. Terasmaa, M. Eller, A. Rinken Effect of denervation of the locus coeruleus projections by DSP-4 treatment on [3H]-raclopride binding to dopamine D2 receptors and D2 receptor – G-protein interaction in the rat striatum. Brain Research (2003) 976: 209-216
80. J. Harro, K. Fischer, S. Vansteelandt, M. Harro Both low and high activity of platelet monoamine oxidase increase the probability of becoming a smoker. European Neuropsychopharmacology (2004) 14: 65-69
81. D. Eensoo, M. Paaver, A. Pulver, M. Harro, J. Harro Low platelet MAO activity associated with high dysfunctional impulsivity and antisocial behaviour: evidence from drunk drivers. Psychopharmacology (2004) 172: 356-358
82. A. Alttoa, J. Harro Effect of CCK1 and CCK2 receptor blockade on amphetamine-stimulated exploratory behaviour and sensitization to amphetamine. European Neuropsychopharmacology (2004) 14: 324-331
83. T. Mällo, C. Berggård, M. Eller, M. Damberg, L. Oreland, J. Harro Effect of long-term blockade of CRF1 receptors on exploratory behavior, monoamines and transcription factor AP-2. Pharmacology Biochemistry & Behavior (2004) 77: 855-865
84. R. Häidkind, M. Eller, A. Kask, M. Harro, A. Rinken, L. Oreland, J. Harro Increased behavioural activity of rats in forced swimming test after partial denervation of serotonergic system by parachloroamphetamine treatment. Neurochemistry International (2004) 45: 721-732
85. E. Kiive, J. Maaroos, J. Shlik, I. Tõru, J. Harro Growth hormone, cortisol and prolactin responses to physical exercise: higher prolactin response in depressed patients. Progress in Neuro-Psychopharmacology & Biological Psychiatry (2004) 28: 1007-1013
86. M. Tõnissaar, M.-A. Philips, M. Eller, J. Harro Sociability trait and serotonin metabolism in the rat social interaction test. Neuroscience Letters (2004) 367: 309-312
87. D. Eensoo, M. Paaver, M. Harro, J. Harro Predicting drunk driving: contribution of alcohol use and related problems, traffic behaviour, personality and platelet monoamine oxidase (MAO) activity. Alcohol & Alcoholism (2005) 40: 140-146
88. A. Alttoa, K. Kõiv, M. Eller, A. Uustare, A. Rinken, J. Harro Effects of low dose N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine administration on exploratory and amphetamine-induced behavior and dopamine D2 receptor function in rats with high or low exploratory activity. Neuroscience (2005) 132: 979-990
89. E. Kiive, L. Merenäkk, M. Harro, J. Harro Changes in platelet monoamine oxidase activity, cholesterol levels and hyperactive behaviour in adolescents over a period of three years. Neuroscience Letters (2005) 384: 310-315
90. S.O. Fetissov, J. Harro, M. Jaanisk, A. Järv, I. Podar, J. Allik, I. Nilsson, P. Sakthivel, A.K. Lefvert, T. Hökfelt Autoantibodies against neuropeptides are associated with psychological traits in eating disorders. Proceedings of the National Academy of Sciences of the U.S.A. (2005) 102: 14865-14870
91. M. Paaver, D. Eensoo, A. Pulver, J. Harro Adaptive and maladaptive impulsivity, platelet monoamine oxidase (MAO) activity and risk-admitting in different types of risky drivers. Psychopharmacology (2006) 186: 32-40
92. J. Harro CCK and NPY as anti-anxiety treatment targets: promises, pitfalls, and strategies. Amino Acids (2006) 31: 215-230
93. K. Laidra, J. Allik, M. Harro, L. Merenäkk, J. Harro Agreement among adolescents, parents and teachers on adolescent personality. Assessment (2006) 13: 187-196
94. M. Tõnissaar, L. Herm, A. Rinken, J. Harro Individual differences in sucrose intake and preference in the rat: circadian variation and association with dopamine D2 receptor function in striatum and nucleus accumbens. Neuroscience Letters (2006) 403: 119-124
95. I. Podar, M. Jaanisk, J. Allik, J. Harro Psychological traits and platelet monoamine oxidase activity in eating disorder patients: their relationship and stability. Progress in Neuro-Psychopharmacology & Biological Psychiatry (2007) 31: 248-253
96. K. Ress, M. Harro, H.-I. Maaroos, J. Harro, R. Uibo, O. Uibo High prevalence of coeliac disease: need for increasing awareness among physicians. Digestive and Liver Disease (2007) 39: 136-139
97. D. Eensoo, M. Harro, H. Pullmann, J. Allik, J. Harro Association of traffic behavior with personality and platelet monoamine oxidase activity in schoolchildren. Journal of Adolescent Health (2007) 40: 311-317
98. A. Alttoa, M. Eller, L. Herm, A. Rinken, J. Harro Amphetamine-induced locomotion, behavioural sensitization to amphetamine, and striatal D2 receptor function in rats with high or low spontaneous exploratory activity: differences in the role of locus coeruleus. Brain Research (2007) 1131: 138-148
99. T. Mällo, A. Alttoa, K. Kõiv, M. Tõnissaar, M. Eller, J. Harro Rats with persistently low or high exploratory activity: behaviour in tests of anxiety and depression, and extracellular levels of dopamine. Behavioural Brain Research (2007) 177: 269-281
100. E. Kiive, K. Fischer, M. Harro, J. Harro Platelet monoamine oxidase activity in association with adolescent inattentive and hyperactive behaviour: A prospective longitudinal study. Personality and Individual Differences (2007) 43: 155-166
101. D. Matrov, I. Kolts, J. Harro Cerebral oxidative metabolism in rats with high and low exploratory activity. Neuroscience Letters (2007) 413: 154-158
102. J. Mäestu, I. Villa, J. Parik, M. Paaver, L. Merenäkk, D. Eensoo, M. Harro, J. Harro Human adrenergic 2A receptor C-1291G polymorphism leads to higher consumption of sweet food products. Molecular Psychiatry (2007) 12: 520-521
103. M. Paaver, N. Nordquist, J. Parik, M. Harro, L. Oreland, J. Harro Platelet MAO activity and the 5-HTT gene promoter polymorphism are associated with impulsivity and cognitive style in visual information processing. Psychopharmacology (2007) 194: 545-554
104. T. Mällo, D. Matrov, L. Herm, K. Kõiv, M. Eller, A. Rinken, J. Harro Tickling-induced 50-kHz ultrasonic vocalization is individually stable and predicts behaviour in tests of anxiety and depression in rats. Behavioural Brain Research (2007) 184: 57-71
105. M. Tõnissaar, T. Mällo, M. Eller, R. Häidkind, K. Kõiv, J. Harro Rat behavior after chronic variable stress and partial lesioning of 5-HT-ergic neurotransmission: effects of citalopram. Progress in Neuro-Psychopharmacology & Biological Psychiatry (2008) 32: 164-177
106. M. Kanarik, D. Matrov, K. Kõiv, M. Eller, M. Tõnissaar, J. Harro Changes in regional long-term oxidative metabolism induced by partial serotonergic denervation and chronic variable stress in rat brain. Neurochemistry International (2008) 52: 432-437
107. J. Mäestu, J. Allik, L. Merenäkk, D. Eensoo, J. Parik, T. Veidebaum, J. Harro Associations between 2A adrenergic receptor gene polymorphism and adolescent personality. American Journal of Medical Genetics B [Neuropsychiatric Genetics] (2008) 147B: 418-423
108. T. Mällo, K. Kõiv, I. Koppel, K. Raudkivi, A. Uustare, A. Rinken, T. Timmusk, J. Harro Regulation of extracellular serotonin levels and brain-derived neurotrophic factor in rats with high and low exploratory activity. Brain Research (2008) 1194: 110-117
109. K. Akkermann, M. Paaver, N. Nordquist, L. Oreland, J. Harro Association of 5-HTT gene polymorphism, platelet MAO activity and drive for thinness in a population-based sample of adolescent girls. International Journal of Eating Disorders (2008) 41: 399-404
110. M. Tõnissaar, L. Herm, M. Eller, K. Kõiv, A. Rinken, J. Harro Rats with high or low sociability are differently affected by chronic variable stress. Neuroscience (2008) 152: 867-876
111. M. Paaver, T. Kurrikoff, N. Nordquist, L. Oreland, J. Harro The effect of 5-HTT promoter polymorphism on impulsivity depends on family relations in girls. Progress in Neuro-Psychopharmacology & Biological Psychiatry (2008) 32: 1263-1268
112. R. Rudissaar, J. Harro, K. Pruus, A. Rinken, L. Allikmets Repeated administration of dopaminergic agonist apomorphine: development of apomorphine aggressiveness and changes in the interaction between dopamine D2 receptors and G-proteins. Pharmacological Reports (2008) 60: 827-833
113. A. Alttoa, P. Seeman, K. Kõiv, M. Eller, J. Harro Rats with persistently high exploratory activity have both higher extracellular dopamine levels and higher proportion of D2High receptors in the striatum. Synapse (2009) 63: 443-446
114. J. Harro, L. Merenäkk, N. Nordquist, K. Konstabel, E. Comasco, L. Oreland Personality and the serotonin transporter gene: Associations in a longitudinal population-based study. Biological Psychology (2009) 81: 9-13
115. A.L. Garcia-Garcia, N. Elizalde, D. Matrov, J. Harro, S.M. Wojcik, E. Venzala, M.J. Ramirez, J. Del Rio, R.M. Tordera Increased vulnerability to depressive-like behaviour of mice with decreased expression of VGLUT1. Biological Psychiatry (2009) 66: 275-282
116. N. Nordquist, C. Göktürk, E. Comasco, D. Eensoo, L. Merenäkk, T. Veidebaum, L. Oreland, J. Harro The transcription factor TFAP2B is associated with insulin resistance and adiposity in healthy adolescents. Obesity (2009) 17: 1762-1767
117. T. Mällo, D. Matrov, K. Kõiv, J. Harro Effect of chronic stress on behavior and cerebral oxidative metabolism in rats with high or low positive affect. Neuroscience (2009) 164: 963-974
118. A. Alttoa, K. Kõiv, T.A. Hinsley, A. Brass, J. Harro Differential gene expression in a rat model of depression based on persistent differences in exploratory activity. European Neuropsychopharmacology (2010) 20: 288-300
119. K. Akkermann, N. Nordquist, L. Oreland, J. Harro Serotonin transporter gene promoter polymorphism affects the severity of binge eating in general population. Progress in Neuro-Psychopharmacology & Biological Psychiatry (2010) 34: 111-114
120. E. Kiive, T. Kurrikoff, J. Mäestu, J. Harro Effect of 2A-adrenoceptor C-1291G genotype and maltreatment on hyperactivity and inattention in adolescents. Progress in Neuro-Psychopharmacology & Biological Psychiatry (2010) 34: 219-224
121. J. Harro Inter-individual differences in neurobiology as vulnerability factors for affective disorders: implications for psychopharmacology. Pharmacology & Therapeutics (2010) 125: 402-422
122. I. Labayen, J. Ruiz, F. Ortega, H.-M. Loit, J. Harro, T. Veidebaum, M. Sjöström Intergenerational cardiovascular disease risk factors involve both maternal and paternal BMI. Diabetes Care (2010) 33: 894-900
123. K. Laas, A. Reif, S. Herterich, D. Eensoo, K.-P. Lesch, J. Harro The effect of a functional NOS1 promoter polymorphism on impulsivity is moderated by platelet MAO activity. Psychopharmacology (2010) 209: 255-261
124. K. Pruus, R. Rudissaar, L. Allikmets, J. Harro The effect of the NMDA receptor antagonist dizocilpine on behavioral manifestations of serotonin and adrenergic antidepressants in rats. Methods and Findings in Experimental and Clinical Pharmacology (2010) 32: 123-128
125. L. Oreland, N. Nordquist, J. Hallman, J. Harro, K.W. Nilsson Environment and the serotonergic system. European Psychiatry (2010) 25: 304-306
126. K. Kõiv, J. Harro Differences in 5-HT1A receptor-mediated hypothermia in rats with low or high exploratory activity. Behavioural Pharmacology (2010) 21: 765-768
127. J. Harro, E. Kiive Droplets of black bile? Development of vulnerability and resilience to depression in young age. Psychoneuroendocrinology (2011) 36: 380-392
128. K. Akkermann, K. Hiio, I. Villa, J. Harro Food restriction leads to binge eating dependent upon the effect of the brain-derived neurotrophic factor Val66Met polymorphism. Psychiatry Research (2011) 185: 39-43
129. X. Gonda, K. Fountolakis, J. Harro, M. Pompili, H. Akiskal, G. Bagdy, Z. Rihmer The possible contributory role of the s allele of 5-HTTLPR in the emergence of suicidality. Journal of Psychopharmacology (in press)
130. A. Reif, E. Kiive, T. Kurrikoff, M. Paaver, S. Herterich, K. Konstabel, T. Tulviste, K.-P. Lesch, J. Harro A functional NOS1 promoter polymorphism interacts with adverse environment on functional and dysfunctional impulsivity. Psychopharmacology (2011) 214: 239-248
131. M. Kanarik, A. Alttoa, D. Matrov, K. Kõiv, T. Sharp, J. Panksepp, J. Harro Brain responses to chronic social defeat stress: effects on regional oxidative metabolism as a function of a hedonic trait, and gene expression in susceptible and resilient rats. European Neuropsychopharmacology (2011) 21: 92-107
132. K. Kõiv, R. Zobel, K. Raudkivi, T. Kivastik, J. Harro The effect of denervation of the locus coeruleus projections with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) on cocaine induced locomotion and place preference in rats. Behavioural Brain Research (2011) 216: 172-179
133. F.D. Garcia, Q. Coquerel, E. Kiive, P. Déchelotte, J. Harro, S.O. Fetissov Autoantibodies reacting with vasopressin and oxytocin in relation to cortisol secretion in mild and moderate depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry (2011) 35: 118-125
134. L. Merenäkk, J. Mäestu, N. Nordquist, J. Parik, L. Oreland, H.-M. Loit, J. Harro Effects of the serotonin transporter (5-HTTLPR) and 2A-adrenoceptor (C-1291G) genotypes on substance use in children and adolescents: a longitudinal study. Psychopharmacology (2011) 215: 13-22
135. K. Hiio, L. Merenäkk, N. Nordquist, J. Parik, L. Oreland, T. Veidebaum, J. Harro Effects of serotonin transporter promoter (5-HTTLPR) and BDNF Val66Met genotype on personality traits in a population representative sample of adolecents. Psychiatric Genetics (in press)
136. F.B. Ortega, J.R. Ruiz, I. Labayen, L. Kwak, J. Harro, L. Oja, T. Veidebaum, M. Sjöström Sleep duration and activity levels in Estonian and Swedish children and adolescents. European Journal of Applied Physiology (in press)
137. D. Matrov, A. Vonk, L. Herm, A. Rinken, J. Harro Activating effects of chronic variable stress in rats with different exploratory activity: Association with dopamine D1 receptor function in nucleus accumbens. Neuropsychobiology (in press)
138. J. Harro, M. Kanarik, D. Matrov, J. Panksepp Mapping patterns of depression-related brain regions with cytochrome oxidase histochemistry: Relevance of animal affective systems to human disorders, with a focus on resilience to adverse events. Neuroscience & Biobehavioral Reviews (in press)
139. F.B. Ortega, I. Labayen, J.R. Ruiz, E. Kurvinen, H.-M. Loit, J. Harro, T. Veidebaum, M. Sjöström Improvements in fitness reduce the risk of becoming overweight across puberty. Medicine & Science in Sports & Exercise (in press)
140. K. Ress, J. Harro, O. Uibo, R. Uibo Use of a fully automated immunoassay for celiac disease screening in a pediatric population. Clinical Chemistry and Laboratory Medicine (2011) 49: 983-987
141. I. Labayen, J.R. Ruiz, F.B. Ortega, J. Harro, L. Merenäkk, L. Oja, T. Veidebaum, M. Sjöström Insulin sensitivity at childhood predicts changes in total and central adiposity over a 6-year period. International Journal of Obesity (in press)
142. S. Oreland, K. Raudkivi, L. Oreland, J. Harro, L. Arborelius, I. Nylander Ethanol-induced effects on the dopamine and serotonin systems in adult Wistar rats are dependent on early-life experiences. Brain Research (in press)

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