Internet and Psychiatry
  • Home
    • Editorials
    • Research news
    • Research papers
    • Interviews with eminent psychiatrists
    • Ten years ago
    • Fifteen years ago
  • Topics
    • Alcohol and Drug Abuse
    • Anxiety Disorders
    • Biomedical Science
    • Compulsive gambling
    • Disaster Medicine
    • Education
    • General Medicine
      • Acupuncture
      • Physical medicine and Rehabilitation
    • Human Rights
    • Interviews with eminent psychiatrists
    • Mood Disorders
      • Bipolar Disorder
      • Depression
      • Seasonal Affective Disorder
    • Neurological Disorders
    • Other Psychiatric Disorders
    • Posttraumatic Stress Disorder
    • Sexual Behavior
  • Books
    • Comorbidity of Depression and Alcohol Use Disorders
    • “Immigration and Mental Health” chapter abstracts
    • “Internet and Suicide” chapter abstracts
    • “Neurobiology of PTSD” chapter abstracts
    • “Suicidal Behavior in Alcohol…” chapter abstracts
    • “Suicide in the Military” chapter abstracts
    • “Terror and Suicide” chapter abstracts
    • “War and Suicide” chapter abstracts
  • Editors
    • Leo Sher, M.D.
    • Alexander Vilens, M.S.
  • Guests
    • Distinguished Guests
    • Our Contributors
  • Reflections
    • Poetry
    • Quotes

Posttraumatic Stress Disorder

Cortisol response to cosyntropin administration in military veterans with or without posttraumatic stress disorder

January 1, 2015

Golier JA, Caramanica K, Makotkine I, Sher L, Yehuda R.
Psychoneuroendocrinology. 2014 Feb;40:151-8.

Abstract. Studies have demonstrated altered sensitivity of the hypothalamic-pituitary-adrenal (HPA) axis to its direct regulators in veterans with posttraumatic stress disorder (PTSD), but little is known about the adrenal response to hormonal stimulation in PTSD. An increased cortisol response to synthetic corticotropin-releasing factor (CRF) was recently found to be associated with war-zone deployment and not PTSD specifically. To more accurately assess whether there is altered adrenocortical responsivity to hormonal stimulation in relation to war-zone deployment or PTSD, we performed the low-dose cosyntropin stimulation test in a sample of 45 male veterans: 13 war-zone exposed veterans with chronic PTSD (PTSD+), 22 war-zone exposed veterans without chronic PTSD (PTSD-), and 10 veterans not exposed to a war-zone and without chronic PTSD (non-exposed).Plasma cortisol and ACTH were measured at baseline and at intervals over a one hour period following intravenous administration of 1µg of cosyntropin. A significant main effect of group (PTSD+, PTSD-, non-exposed) on the cortisol response to cosyntropin was observed. Cosyntropin-stimulated plasma cortisol levels were significantly higher in the PTSD+ and PTSD- groups compared to the non-exposed group. A significant main effect of group was also observed on peak cortisol levels. These findings suggest that war-zone exposure itself has persistent effects on adrenocortical activity.

Related Posts

Posttraumatic Stress Disorder /

Translational evidence for a role of endocannabinoids in the etiology and treatment of posttraumatic stress disorder

Posttraumatic Stress Disorder /

Family support, family stress and suicidal ideation in a combat-exposed sample of OEF/OIF Veterans

Posttraumatic Stress Disorder /

The role of nutrients in protecting mitochondrial function and neurotransmitter signaling: implications for the treatment of depression, PTSD, and suicidal behaviors

‹ Suicidal behavior in a medical professional with comorbid depression and substance use disorder: an educational case report › The role of serotonin in adolescent suicide: theoretical, methodological, and clinical concerns

Editorials

  • COVID-19 and suicide
  • Pregnancy and COVID-19
  • Physician distress and relief during the coronavirus pandemic
  • Challenges associated with patients refusing to eat in inpatient psychiatric setting

Research Papers

  • Examination of depressive signs and symptoms among 803 University students in seven Universities and Colleges. Hungary, Romania, Serbia.
  • Examination of spirituality and the dimensions of spirituality among 803 students in seven different Universities. Hungary, Romania and Serbia.
  • Examination of depressive signs and symptoms among 932 students in eight different secondary schools in Hungary
  • Examination of psychological immune system among 932 students in eight different secondary schools in Hungary

Research News

  • Bidirectional relations between COVID-19 and psychiatric disorders
  • Mental health problems among healthcare professionals during the COVID-19 crisis
  • Depression and cardiometabolic health: a longitudinal study
  • Testosterone levels in combat veterans with or without a history of suicide attempt

Latest News

  • American Psychiatric Association Position Statement on Use of the Terms Client and Provider
  • Leading world experts on suicide. Expertscape, the January 31, 2021 report
  • Leading world experts on suicide. Expertscape, December 2020
  • 9-8-8 will be the universal telephone number to reach the national suicide prevention and mental health crisis hotline

Interviews with eminent psychiatrists

  • Interview with Professor Shih-Ku Lin
  • Interview with Professor Masahito Fushimi
  • Interview with Professor Maurizio Pompili
  • Interview with Professor Marco Sarchiapone

Ten Years Ago

  • Posttraumatic stress disorder and the Neuroevolutionary Time-depth Principle
  • The role of endogenous opioids and monoamine neurotransmitters in non-suicidal self-injury
  • The 2003 SARS outbreak and suicide among older adults
  • Objections to suicide among mood disordered patients with co-occurring alcohol use disorders

Back to Top

  • About
  • Contact
  • Privacy Policy
  • Terms and Conditions
Copyright © 2021 AVCalc LLC. All rights reserved worldwide.