The Effect of Early Trauma Exposure on Serotonin Type 1B Receptor Expression Revealed by Reduced Selective Radioligand Binding

Murrough JW, Czermak C, Henry S, Nabulsi N, Gallezot JD, Gueorguieva R, Planeta-Wilson B, Krystal JH, Neumaier JF, Huang Y, Ding YS, Carson RE, Neumeister A.Arch Gen Psychiatry. 2011 Sep;68(9):892-900. CONTEXT: Serotonergic dysfunction is implicated in the pathogenesis of posttraumatic stress disorder (PTSD), and recent animal models suggest that disturbances in serotonin type 1B receptor […]

Possible role of BDNF-induced microglial intracellular Ca(2+) elevation in the pathophysiology of neuropsychiatric disorders

Mizoguchi Y, Monji A, Kato TA, Horikawa H, Seki Y, Kasai M, Kanba S, Yamada S.Mini Rev Med Chem. 2011 Jun;11(7):575-81. Microglia are intrinsic immune cells that release factors, including proinflammatory cytokines, nitric oxide (NO) and neurotrophins, following activation after disturbance in the brain. Elevation of intracellular Ca(2+) concentration ([Ca(2+)]i) is important for microglial functions, […]

Hopelessness, temperament, anger and interpersonal relationships in Holocaust (Shoah) survivors’ grandchildren

Iliceto P, Candilera G, Funaro D, Pompili M, Kaplan KJ, Markus-Kaplan M.J Relig Health. 2011 Jun;50(2):321-9. The psychiatric literature is divided with regard to the long-term psychological effects associated with Holocaust (Shoah) experiences because the findings of clinical and empirical studies often contradict each other. Despite case reports of emotional sequelae related to intergenerational transmission […]

An evolutionary hypothesis of suicide: why it could be biologically adaptive and is so prevalent in certain occupations

Tanaka M, Kinney DK.Psychol Rep. 2011 Jun;108(3):977-92. From an evolutionary perspective, suicide is a puzzle, because it has serious adverse effects, yet is remarkably common and heritable. An hypothesis is proposed to explain this puzzle, by explaining how suicide could be adaptive through reducing risk that individuals will transmit infections to kin. Empirical evidence supports […]

A Model of Suicidal Behavior among Immigrants with Psychiatric Disorders

Leo Sher Columbia University and New York State Psychiatric Institute, New York, New York, USA Immigration and Mental Health: Stress, Psychiatric Disorders and Suicidal Behavior Among Immigrants and Refugees. Hauppauge, New York: Nova Science Publishers, 2010, 350 pages. The term “immigration” is usually used to denote international immigration. The United Nations considers a long term […]

Immigration and Suicide: An Overview

Brian Greenfield(1), Londa Daniel(2) and Bonnie Harnden(2) 1. McGill University Faculty of Medicine and Montreal Children’s Hospital, Montreal, Quebec, Canada 2. Concordia University, Montreal, Quebec, Canada Immigration and Mental Health: Stress, Psychiatric Disorders and Suicidal Behavior Among Immigrants and Refugees. Hauppauge, New York: Nova Science Publishers, 2010, 350 pages. Introduction: The assessment of patients contemplating […]

Immigrants and Suicidal Behavior: The Role of Gender

Diana van Bergen(1) and Sawitri Saharso(2) 1. The Netherlands Institute for Social Research, The Hague; 2. VU University Amsterdam and University Twente,The Netherlands Immigration and Mental Health: Stress, Psychiatric Disorders and Suicidal Behavior Among Immigrants and Refugees. Hauppauge, New York: Nova Science Publishers, 2010, 350 pages. Ethnicity plays a major role in the rates and […]

Suicidal Behavior among Hispanic Immigrants in the United States

Guilherme Borges(1,3), Liliana Mondragón(1) and Joshua Breslau(2) 1. National Institute of Psychiatry, México City, México 2. UC Davis School of Medicine, Sacramento, California, USA 3. Universidad Autonoma Metropolitana, México City, México Immigration and Mental Health: Stress, Psychiatric Disorders and Suicidal Behavior Among Immigrants and Refugees. Hauppauge, New York: Nova Science Publishers, 2010, 350 pages. At […]

The MMI Marathon

Allison M. Greene and Christopher R. Bailey Medical schools are continually developing novel strategies for recruiting students with the qualities that they believe will produce successful doctors.  Intelligence and academic achievement, attributes that are relatively straightforward to evaluate, were once the cruxes of the interview process. But people skills are becoming increasingly paramount and despite […]

Celexa (citalopram hydrobromide) may cause changes in the electrical activity of the heart

Leo Sher, M.D. The U.S. Food and Drug Administration (FDA) has informed healthcare professionals and patients that the antidepressant Celexa (citalopram hydrobromide; also marketed as generics) should no longer be used at doses greater than 40 mg per day because it can cause abnormal changes in the electrical activity of the heart. Studies did not […]

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