Posttraumatic stress disorder, substance use disorders, and medical comorbidity among returning U.S. veterans

Nazarian D, Kimerling R, Frayne SM.J Trauma Stress. 2012 Apr;25(2):220-5. AbstractEvidence suggests that posttraumatic stress disorder (PTSD) and substance use disorders (SUD) are associated with poorer physical health among U.S. veterans who served in Operation Enduring Freedom and Operation Iraqi Freedom (OEF/OIF). No research of which we are aware has examined the independent and interactive […]

The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force recommendations for the management of patients with mood disorders and comorbid personality disorders

Rosenbluth M, Macqueen G, McIntyre RS, Beaulieu S, Schaffer A; Canadian Network for Mood and Anxiety Treatments (CANMAT) Task Force.Ann Clin Psychiatry. 2012 Feb;24(1):56-68. AbstractBACKGROUND: The association between mood disorders and personality disorders (PDs) is complicated clinically, conceptually, and neurobiologically. There is a need for recommendations to assist clinicians in treating these frequently encountered patients. […]

The relationship between loss of parents in the Holocaust, intrusive memories, and distress among child survivors

Letzter-Pouw S, Werner P.Am J Orthopsychiatry. 2012 Apr;82(2):201-8 AbstractThe prevalence of intrusive memories of the Holocaust and their relationship to distress was examined among 272 child survivors in Israel. Using attachment theory as a conceptual framework, the authors also examined the effects of type of experience and loss of parents in the Holocaust, psychological resources, […]

On- and off-target pharmacology of torcetrapib: current understanding and implications for the structure activity relationships (SAR), discovery and development of cholesteryl ester-transfer protein (CETP) inhibitors

Johns DG, Duffy J, Fisher T, Hubbard BK, Forrest MJ.Drugs. 2012 Mar 5;72(4):491-507. AbstractLowering of serum low-density lipoprotein cholesterol (LDL-C) levels remains the primary aim of lipid management. Much progress has been made in reducing rates of cardiovascular disease morbidity and mortality, largely through increased awareness of lipid-lowering therapies and particularly through the use of […]

Are Selective Serotonin Reuptake Inhibitors Safe for Drivers? What is the Evidence?

Ravera S, Ramaekers JG, de Jong-van den Berg LT, de Gier JJ.Clin Ther. 2012 May 1. [Epub ahead of print] AbstractBACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) are widely used medications to treat several psychiatric diseases and, above all, depression. They seem to be as effective as older antidepressants but have a different adverse effect profile. […]

Azithromycin and the risk of death

Leo Sher, M.D. The U.S. Food and Drug Administration (FDA) has notified healthcare professionals of a new study (1) reporting a small increase in cardiovascular death, and in the risk of death from any cause, in patients treated with a 5-day course of azithromycin (Zithromax; Pfizer) compared to individuals treated with amoxicillin, ciprofloxacin, or no […]

Glucocorticoid receptor number predicts increase in amygdala activity after severe stress

Geuze E, van Wingen GA, van Zuiden M, Rademaker AR, Vermetten E, Kavelaars A, Fernández G, Heijnen CJ.Psychoneuroendocrinology. 2012 Apr 11. [Epub ahead of print] AbstractINTRODUCTION: Individuals who are exposed to a traumatic event are at increased risk of developing psychiatric disorders such as posttraumatic stress disorder (PTSD). Studies have shown that increased amygdala activity […]

Ever Heard of ORTHOREXIA?

Steven Lippmann, M.D. Could healthy eating habits be bad? Good nutrition and careful food selection sounds just great and indeed they are. We all applaud healthy eating. However, like any behavior, too much of it, can become counter-productive or even dangerous. Excessive adherence to an overly rigid diet can become physically unhealthy and hamper social […]

Would You Recognize A Frontotemporal Dementia?

Steven Lippmann, M.D. Frontotemporal dementia (FTD) is a progressive dementing illness starting during middle to older life. This neurodegenerative brain disease of the frontal and temporal lobes results in personality, behavioral, and language alterations. These clinical features are much more prominent than the forgetfulness and diminished cognition of most other dementing illnesses.

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