A new article on the clinical significance and construct validity of hypomania and bipolar II disorder

Leo Sher, M.D. Prof. Zoltan Rihmer and his colleagues have recently published an interesting Editorial entitled, “Hypomania and bipolar II disorder – diagnostic validity and clinical utility.” This article was published in Psychiatria Hungarica (2013; 28:345-348). Most readers of our web site, www.internetandpsychiatry.com do not have access to articles published in this Journal. The Editors […]

A new review article on the prevention of suicide in patients with mood disorders

Leo Sher, M.D. Professor Zoltan Rihmer, an eminent psychiatrist and a leading world expert in psychiatric research, and his colleague, Professor Xenia Gonda have published the article, “Pharmacological prevention of suicide in patients with major mood disorders” (1). Mood disorders are frequently associated with suicidal behavior. Between 5 and 15% of patients with unipolar major […]

Heroin-assisted treatment

Leo Sher, M.D. Heroin (diacetylmorphine, (5a,6a)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol diacetate (ester), diamorphine, or Diagesil®) is a semi-synthetic morphine derivative and a powerful opioid analgesic (1). Heroin was created in 1874 by Dr. Charles Romley Alder Wright, a British chemistry and physics researcher who worked at St. Mary’s Hospital Medical School in London (2). Heroin was first marketed in […]

80-90% of suicide cases had depression: fact or speculation?

Said Shahtahmasebi, Ph.D. You know, when I was at primary school and subsequently high school my teachers used to tell me and other vertically challenged students to play basketball so we would become tall. Well, because I was young and because society at that time had faith in authority, in particular, teachers and doctors, I […]

Is there a right to prescription privacy?

Jacob M. Appel, M.D., J.D. Concern over “doctor shopping”—the practice of obtaining prescriptions for controlled substance from multiple physicians under false pretenses—has led to a complex patchwork of state laws to track and punish abusers.  At the federal level, the Uniform Controlled Substances Act of 1970 prohibits patients from obtaining scheduled medication through “misrepresentation, fraud, […]

Breastfeeding history affects women’s risk of Alzheimer’s disease

Leo Sher, M.D. Considerable evidence suggests that that breastfeeding history may affect maternal disease risk. For example, longer breastfeeding history is associated with lower rates of osteoporosis. It has also been proposed that there may be a connection between the physiological effects of lactation and Alzheimer’s disease. A new research report published in the Journal […]

Maternal breastfeeding history and Alzheimer’s disease risk

Fox M, Berzuini C, Knapp LA. J Alzheimers Dis. 2013 Jul 23. [Epub ahead of print] AbstractThe effect of early and midlife factors on later-life cognitive function has attracted scientific and public interest in recent years, especially with respect to hormonal risk factors for dementia. There is substantial evidence for reproductive history affecting Alzheimer’s disease (AD) […]

European College of Neuropsychopharmacology (ECNP) News

Leo Sher, M.D. has been accepted as a Corresponding Member of the European College of Neuropsychopharmacology (ECNP). According to the ECNP web site, “Corresponding membership is available for eminent researchers in the field of neuropsychopharmacology and related disciplines who are not permanently resident in Europe.”

Low testosterone levels may be associated with suicidal behavior in older men while high testosterone levels may be related to suicidal behavior in adolescents and young adults: a hypothesis

Sher L.Int J Adolesc Med Health. 2013;25(3):263-8. Abstract Several lines of evidence suggest that there is an association between testosterone and suicidal behavior. A link between testosterone and the neurobiology of suicidal behavior may be related to: a) a direct effect of testosterone on suicidality via certain brain mechanisms; and/or b) a testosterone influence on […]

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