T. E. Thiele1, 4; M. Navarro4; I. Cubero5; D. J. Knapp2, 4; G. R. Breese3, 4 1. Psychology, University of North Carolina, Chapel Hill, NC, USA. 2. Psychiatry, University of North Carolina, Chapel Hill, NC, USA. 3. Pharmacology, University of North Carolina, Chapel Hill, NC, USA. 4. Bowles Center for Alcohol Studies, University of North […]
J. M. Littleton. Kentucky Tobacco Research & Development Center, University of Kentucky, Lexington, KY, USA. Effective medications for drug and alcohol dependence are greatly needed, but progress has been slow. One problem is that, although several molecular targets can be identified, many of these present specific difficulties. For example it is quite clear that nicotinic […]
Haynes JC, Farrell M, Singleton N, Meltzer H, Araya R, Lewis G, Wiles NJ. Br J Psychiatry. 2005 Dec;187:544-51. BACKGROUND: Longitudinal studies have been inconclusive in identifying alcohol as a risk factor for anxiety and depression. AIMS: To examine whether excessive alcohol consumption is a risk factor for anxiety and depression in the general population, […]
Deardorff J, Gonzales NA, Christopher FS, Roosa MW, Millsap RE. Pediatrics. 2005 Dec;116(6):1451-6. OBJECTIVE: Early pubertal timing predicts deleterious outcomes for young girls, including substance use, risky sexual behavior, and pregnancy. In turn, adolescent pregnancy predicts long-term negative consequences such as reduced educational attainment and income-earning potential. Despite evidence of the direct links between early […]
Thom B. Am J Addict. 2005 Oct-Dec;14(5):416-25. With the publication of the Alcohol Harm Reduction Strategy for England in 2004,(1) it is timely to reflect on the social and political contexts that have influenced alcohol policy. This paper provides an overview of trends in the development of alcohol policy in England since 1950 with a […]
Hines LM, Ray L, Hutchison K, Tabakoff B. Dialogues Clin Neurosci. 2005;7(2):153-63. Alcohol dependence (alcoholism) is a complex disorder attributed to the interaction of genetic and environmental factors that form a collage of “disease” predisposition, which is not identical for every alcohol-dependent individual. There is considerable evidence to demonstrate that genetic predisposition accounts for roughly […]
Egli M. Addict Biol. 2005 Dec;10(4):309-19. Evaluating medications in animal laboratory paradigms can reveal whether the compound is effective in an established alcoholism model, at clinically relevant doses and exposure conditions, when administered orally (or transdermally) and without serious limiting side effects. Positive outcomes constitute a possible discovery for relevance to alcoholism and, under favorable […]
Allen GC, West JR, Chen WJ, Earnest DJ. Alcohol Clin Exp Res. 2005 Oct;29(10):1845-52. BACKGROUND: Alcohol exposure during the period of rapid brain development produces structural damage in different brain regions, including the suprachiasmatic nucleus (SCN), that may have permanent neurobehavioral consequences. Thus, this study examined the long-term effects of neonatal alcohol exposure on circadian […]
Sher L. Med Hypotheses. 2005 Dec; 65(6):1010-2. Alcohol use and abuse substantially influence suicide rates. Suicide is a cause of death for a substantial percentage of individuals with alcoholism. However, the results of epidemiological studies of the relation between alcohol use and suicide have been inconsistent. Studies conducted in one nation are not always applicable […]
Ganguli M, Vander Bilt J, Saxton JA, Shen C, Dodge HH. Neurology. 2005 Oct 25;65(8):1210-7. OBJECTIVE: To examine the association between alcohol use and cognitive decline in a longitudinal study of a representative elderly community sample free of dementia at baseline.
