McKowen JW, Frye MA, Altshuler LL, Gitlin MJ. Bipolar Disord. 2005 Aug;7(4):377-81. OBJECTIVES: Despite a high prevalence rate, patients with bipolar disorder and active alcohol use are routinely excluded from controlled clinical trials leaving clinicians with little evidence-based medicine to guide treatment. This report evaluates preliminary data of alcohol consumption patterns utilizing the Alcohol Timeline […]
Effects of co-occurring alcohol abuse on the course of bipolar disorder following a first hospitalization for mania
Strakowski SM, DelBello MP, Fleck DE, Adler CM, Anthenelli RM, Keck PE Jr, Arnold LM, Amicone J. Arch Gen Psychiatry. 2005 Aug;62(8):851-8. CONTEXT: Alcohol-use disorders are common co-occurring conditions affecting bipolar patients, and this co-occurrence is negatively associated with outcome. OBJECTIVE: The primary goal of this study was to identify how the relative onsets of […]
Endocannabinoid lipids and mediated system: Implications for alcoholism and neuropsychiatric disorders
Vinod KY, Hungund BL. Life Sci. 2005 Aug 19;77(14):1569-83. Several natural lipids have emerged as candidate modulators of central nervous system (CNS) functions. Fatty acid amides and their coupled signaling pathways are known to regulate several physiological and behavioral processes. Recent studies from our laboratory and others also have implicated endogenous marijuana-like brain constituents, endocannabinoids […]
Scanning of genetic effects of alcohol metabolism gene (ADH1B and ADH1C) polymorphisms on the risk of alcoholism
Choi IG, Son HG, Yang BH, Kim SH, Lee JS, Chai YG, Son BK, Kee BS, Park BL, Kim LH, Choi YH, Shin HD. Hum Mutat. 2005 Sep;26(3):224-34. Alcoholism is a multifactorial and polygenic disorder involving complex gene-to-gene and gene-to-environment interactions. Alcohol metabolism is one of the biological determinants that could significantly be influenced by […]
A new method of linkage analysis using LOD scores for quantitative traits supports linkage of monoamine oxidase activity to D17S250 in the Collaborative Study on the Genetics of Alcoholism pedigrees
Curtis D, Knight J, Sham PC. Psychiatr Genet. 2005 Sep;15(3):181-187 OBJECTIVE: Although LOD score methods have been applied to diseases with complex modes of inheritance, linkage analysis of quantitative traits has tended to rely on non-parametric methods based on regression or variance components analysis. Here, we describe a new method for LOD score analysis of […]
Kohnke MD, Batra A, Kolb W, Kohnke AM, Lutz U, Schick S, Gaertner I. Alcohol Alcohol. 2005 Sep-Oct;40(5):339-42. AIMS: It was investigated whether the allele A9 of the dopamine transporter gene (DAT1; SLC6A3) is associated with alcoholism, delirium tremens (DT), alcohol withdrawal seizures (AWS), or the daily alcohol intake.
Increasing leptin precedes craving and relapse during pharmacological abstinence maintenance treatment of alcoholism
Kiefer F, Jahn H, Otte C, Demiralay C, Wolf K, Wiedemann K. J Psychiatr Res. 2005 Sep;39(5):545-551. The appetite regulating peptide leptin has recently been associated with craving for alcohol and lifetime ethanol intake. However, effects of anti- craving drugs on leptin have not been studied until now.
Researchers from Columbia University Medical Center in New York mapped out the specific areas of the hippocampus impacted by late-life diseases like diabetes and stroke. The researchers found that decreasing activity in the dentate gyrus correlated with levels of blood glucose. Dentate gyrus is part of the hippocampal formation which is thought to contribute to […]
Echeburua E, de Corral P. Adicciones. 2008;20(4):321-5. This paper deals with the new development of controlled gambling embedded in a harm-reduction context as a viable solution both for primary prevention at school and for treatment of some kinds of problematic gamblers. Pathological gambling significantly improves with psychological therapies, such as stimulus control and in vivo […]
Barnes GM, Welte JW, Hoffman JH, Tidwell MC.Research Institute on Addictions, University at Buffalo, 1021 Main Street, Buffalo, New York 14203. J Stud Alcohol Drugs. 2009 Jan;70(1):134-42. Objective: Problem gambling has been linked with substance misuse among youth in a number of regional studies, yet there have been no large representative U.S. surveys of gambling […]