Leo Sher, M.D. Our research paper, “Lower CSF homovanillic acid levels in depressed patients with a history of alcoholism” was published 20 years ago, in the September 2003 issue of Neuropsychopharmacology (1). We compared clinical features and cerebrospinal fluid (CSF) monoamine metabolites in depressed subjects with or without a history of alcoholism and healthy volunteers. […]
Leo Sher, M.D. Our research report, “Prolactin response to fenfluramine administration in patients with unipolar and bipolar depression and healthy controls” was published 20 years ago, in the May 2003 issue of Psychoneuroendocrinology (1). The serotonergic system plays an important role in the etiology and pathogenesis of mood disorders. Studies suggest that a deficit in […]
Leo Sher, M.D. Our research work, “A longer biological night in long sleepers than in short sleepers” was published 20 years ago in the January 2003 issue of the Journal of Clinical Endocrinology and Metabolism (1). Habitual sleep duration varies considerably among people. We wanted to determine whether individual differences in sleep duration are associated […]
Leo Sher, M.D. Our research work, “Patients with seasonal affective disorder have lower odor detection thresholds than control subjects” was published 20 years ago in the December 2002 issue of Archives of General Psychiatry (1). Behavioral changes in patients with seasonal affective disorder resemble seasonal changes in photoperiodic animals. The olfactory system has a modulatory […]
Leo Sher, M.D. Our research report, “A circadian signal of change of season in individuals with seasonal affective disorder” was published in the December 2001 issue of the Archives of General Psychiatry (1). In animals, the circadian pacemaker regulates seasonal changes in behavior by transmitting a signal of day length to other sites in the […]
Leo Sher, M.D. Our research paper, “Early response to light therapy partially predicts long-term antidepressant effects in patients with seasonal affective disorder” was published 20 years ago in the September 2001 issue of the Journal of Psychiatry and Neuroscience (1). The aim of the study was to determine if the antidepressant effect of 1 hour […]
Leo Sher, M.D. Our research article, “Evidence from the waking electroencephalogram that short sleepers live under higher homeostatic sleep pressure than long sleepers” was published 20 years ago in the March 2001 issue of Neuroscience (1). We used the waking electroencephalogram to study the homeostatic sleep regulatory process in human short sleepers and long sleepers. […]
Leo Sher, M.D. Our research report, “Pleiotropy of the serotonin transporter gene for seasonality and neuroticism” was published 20 years ago in the September 2000 issue of Psychiatric Genetics (1). Pleiotropy refers to the ability of a single gene to influence multiple traits. A polymorphism in the regulatory region of the serotonin transporter gene (5-HTTLPR) […]
Leo Sher, M.D. Our research paper, “Free thyroxine and thyroid-stimulating hormone levels in patients with seasonal affective disorder and matched controls” was published 20 years ago in the December 1999 issue of the Journal of Affective Disorders (1). Seasonal affective disorder (SAD) is characterized by seasonal changes in mood and neurovegetative function. Depressions in fall […]
Leo Sher, M.D. Our research note, “Seasonality associated with the serotonin transporter promoter repeat length polymorphism” was published in the November 1999 issue of the American Journal of Psychiatry (1). The propensity of people to exhibit changes in mood and behavior with the changing seasons, also known as seasonality, can be viewed as a continuum […]
