Can experimental paradigms and animal models be used to discover clinically effective medications for alcoholism?
Egli M. Addict Biol. 2005 Dec;10(4):309-19. Evaluating medications in animal laboratory paradigms can reveal whether the compound is effective in an established alcoholism model, at clinically relevant doses and exposure conditions, when administered orally (or transdermally) and without serious limiting side effects. Positive outcomes constitute a possible discovery for relevance to alcoholism and, under favorable […]