{"id":2669,"date":"2021-06-29T19:22:27","date_gmt":"2021-06-30T00:22:27","guid":{"rendered":"https:\/\/www.internetandpsychiatry.com\/wp\/?p=2669"},"modified":"2022-01-22T13:22:38","modified_gmt":"2022-01-22T18:22:38","slug":"severe-mental-illness-and-course-of-covid-19","status":"publish","type":"post","link":"https:\/\/www.internetandpsychiatry.com\/wp\/research-news\/severe-mental-illness-and-course-of-covid-19\/","title":{"rendered":"Severe mental illness and course of COVID-19"},"content":{"rendered":"\n
\n <\/div>\n\n\n

Leo Sher, M.D.<\/em><\/p>\n

A research paper, \u201cSevere mental illness is associated with increased mortality and severe course of COVID-19\u201d has recently been published in Acta Psychiatrica Scandinavica <\/em>online ahead of print (1).<\/p>\n

In Denmark, nationwide administrative registries contain information on various healthcare-related and administrative variables. The unique and permanent civil registration number allows cross-linkage of the registries at an individual level. The authors of this study identified all patients with a positive real-time reverse transcription-polymerase chain reaction test for COVID-19 in Denmark up to and including 2 January 2021. Multivariable cox regression was used to calculate 30-day absolute risk and average risk ratio (ARR) for the composite end point of death from any cause and severe COVID-19 associated with psychiatric disorders, defined using both hospital diagnoses and redemption of psychotropic drugs.<\/p>\n

In all, 144,321 individuals with COVID-19 were included in the study. Of these, 984 (0.7%) had a schizophrenia spectrum disorder, 485 (0.3%) bipolar disorder, 3764 (2.6%) unipolar depression, 7328 (5.1%) other psychiatric disorders and 4479 (3.1%) were in treatment with psychotropic drugs without having a hospital psychiatric diagnosis.<\/p>\n

Compared with patients without psychiatric disorders, the standardized ARR of the composite outcome was significantly increased for patients with severe mental illness including schizophrenia spectrum disorders 2.43 (95% confidence interval [CI], 1.79-3.07), bipolar disorder 2.11 (95% CI, 1.25-2.97), unipolar depression 1.70 (95% CI, 1.38-2.02), and for patients who redeemed psychotropic drugs 1.70 (95% CI, 1.48-1.92). No association was found for patients with other psychiatric disorders 1.13 (95% CI, 0.86-1.38). Similar results were seen with the outcomes of death or severe COVID-19. Among the different psychiatric subgroups, patients with schizophrenia spectrum disorders had the highest 30-day absolute risk for the composite outcome 3.1% (95% CI, 2.3-3.9%), death 1.2% (95% CI, 0.4-2.0%) and severe COVID-19 2.7% (95% CI, 1.9-3.6%).<\/p>\n

The authors concluded that a medical history of schizophrenia spectrum disorders, bipolar disorder or unipolar depression or a psychiatric disorder requiring active medical treatment may represent a substantial risk factor for an unfavourable outcome in patients with COVID-19.<\/p>\n

Reference<\/p>\n

    \n
  1. Barcella CA, Polcwiartek C, Mohr GH, Hodges G, S\u00f8ndergaard K, Niels Bang C, Andersen MP, Fosb\u00f8l E, K\u00f8ber L, Schou M, Torp-Pedersen C, Kessing LV, Gislason G, Kragholm K. Severe mental illness is associated with increased mortality and severe course of COVID-19. Acta Psychiatr Scand. 2021 Apr 24. doi: 10.1111\/acps.13309. Epub ahead of print.<\/li>\n<\/ol>\n\n\n

    <\/p>","protected":false},"excerpt":{"rendered":"

    Leo Sher, M.D. A research paper, \u201cSevere mental illness is associated with increased mortality and severe course of COVID-19\u201d has recently been published in Acta Psychiatrica Scandinavica online ahead of print (1). In Denmark, nationwide administrative registries contain information on various healthcare-related and administrative variables. The unique and permanent civil registration number allows cross-linkage of […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-2669","post","type-post","status-publish","format-standard","hentry","category-research-news","has-post-title","has-post-date","has-post-category","has-post-tag","has-post-comment","has-post-author",""],"builder_content":"","_links":{"self":[{"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/posts\/2669","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/comments?post=2669"}],"version-history":[{"count":3,"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/posts\/2669\/revisions"}],"predecessor-version":[{"id":2672,"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/posts\/2669\/revisions\/2672"}],"wp:attachment":[{"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/media?parent=2669"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/categories?post=2669"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/tags?post=2669"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}