{"id":257,"date":"2009-01-26T02:35:22","date_gmt":"2009-01-26T07:35:22","guid":{"rendered":""},"modified":"2022-01-22T13:24:50","modified_gmt":"2022-01-22T18:24:50","slug":"association-of-the-dopamine-transporter-gene-with-alcoholism","status":"publish","type":"post","link":"https:\/\/www.internetandpsychiatry.com\/wp\/topics\/alcohol-and-drug-abuse\/association-of-the-dopamine-transporter-gene-with-alcoholism\/","title":{"rendered":"Association of the dopamine transporter gene with alcoholism"},"content":{"rendered":"<p>Kohnke MD, Batra A, Kolb W, Kohnke AM, Lutz U, Schick S, Gaertner I.  Alcohol Alcohol. 2005 Sep-Oct;40(5):339-42.<\/p>\n<p> <strong>AIMS:<\/strong> It was investigated whether the allele A9 of the dopamine transporter  gene (DAT1; SLC6A3) is associated with alcoholism, delirium tremens  (DT), alcohol withdrawal seizures (AWS), or the daily alcohol intake.<br \/>\n<!--more--><\/p>\n<p> <strong>METHODS:<\/strong> A group of 102 healthy subjects and 216 alcoholics, including  97 patients with a history of mild withdrawal symptoms, 65 with a history of  AWS and 83 with a history of DT were genotyped and personal data were  achieved for statistical evaluation in a case-control design.<\/p>\n<p> <strong>RESULTS:<\/strong> The  frequency of individuals carrying the allele A9 [f(A9+)] was significantly  higher (P = 0.01) in the group of alcoholics [f(A9+) = 0.48] compared with  healthy controls [f(A9+) = 0.32]. There was no significant association of the  allele A9 with severe withdrawal symptoms or the daily amount of alcohol  consumed.<\/p>\n<p> <strong>CONCLUSIONS:<\/strong> Our results reveal that the allele A9 is strongly  associated with alcoholism but not with withdrawal symptoms or daily  alcohol intake.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kohnke MD, Batra A, Kolb W, Kohnke AM, Lutz U, Schick S, Gaertner I. Alcohol Alcohol. 2005 Sep-Oct;40(5):339-42. AIMS: It was investigated whether the allele A9 of the dopamine transporter gene (DAT1; SLC6A3) is associated with alcoholism, delirium tremens (DT), alcohol withdrawal seizures (AWS), or the daily alcohol intake.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-257","post","type-post","status-publish","format-standard","hentry","category-alcohol-and-drug-abuse","has-post-title","has-post-date","has-post-category","has-post-tag","has-post-comment","has-post-author",""],"builder_content":"","_links":{"self":[{"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/posts\/257","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/comments?post=257"}],"version-history":[{"count":1,"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/posts\/257\/revisions"}],"predecessor-version":[{"id":3589,"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/posts\/257\/revisions\/3589"}],"wp:attachment":[{"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/media?parent=257"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/categories?post=257"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.internetandpsychiatry.com\/wp\/wp-json\/wp\/v2\/tags?post=257"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}