An Independent International Scientific Web Site to Promote Intellectual Values

Topics Post-Traumatic Stress Disorder Study on serum cytokine levels in posttraumatic stress disorder patients

Study on serum cytokine levels in posttraumatic stress disorder patients

Guo M, Liu T, Guo JC, Jiang XL, Chen F, Gao YS.
Asian Pac J Trop Med. 2012 Apr;5(4):323-5.

Abstract
OBJECTIVE: To evaluate serum IL-2, IL-4, IL-6, IL-8, IL-10 and TNF-a levels in posttraumatic stress disorder (PTSD) patients. METHODS: We utilized ELISA technology to examine cytokines such as IL-2, IL-4, IL-6, IL-8, IL-10 and TNF-a in serum from 50 well-characterized individuals with a primary DSM-IV PTSD diagnosis, and 50 age- and gender-matched healthy controls. We conservatively employed a Mann-Whitney U testing. RESULTS: Individuals with primary PTSD had significantly elevated peripheral cytokine levels for all 6 different cytokines compared to age- and gender-matched healthy controls (all P<0.01). CONCLUSIONS: These findings suggest that a generalized inflammatory state may be present in individuals with PTSD.

Related Articles