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Seasonal Affective Disorder

Leo Sher, M.D.Seasonal Affective Disorder

The syndrome of "seasonal affective disorder" (SAD) is a condition where depressions in fall and winter alternate with nondepressed periods in the spring and summer. It has been suggested that in order to be diagnosed as having SAD a patient must met the following criteria: a history of major affective disorder; at least two consecutive previous years in which the depressions developed during fall or winter and remitted by the following spring and summer; absence of any other Axis I psychiatric disorders; and absence of any clear-cut seasonality changing psychosocial variables that would account for the seasonal variability in mood and behavior. An opposite pattern, depressions in the summer and non-depressed periods in the winter ("summer SAD"), has also been described. These two types of SAD probably represent a subset of a variety of seasonal behavioral disorders. SAD has been included in the Revised Third Edition and in the Fourth Edition of the "Diagnostic and Statistical Manual of Mental Disorders " of the American Psychiatric Association as "seasonal pattern", an adjectival modifier of any form of seasonally recurrent mood disorders.
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Controlled trial of naturalistic dawn simulation and negative air ionization for seasonal affective disorder

Terman M, Terman JS.
Department of Biopsychology, New York State Psychiatric Institute, New York, NY, USA.
Am J Psychiatry. 2006 Dec;163(12):2126-33.

OBJECTIVE: This trial assessed two novel nonpharmaceutical treatments for winter depression-naturalistic dawn simulation and high-density negative air ionization-delivered during the final hours of sleep.
METHOD: The patients were 99 adults (77 women and 22 men) with the winter seasonal pattern of major depressive disorder (94 cases) and bipolar II disorder (five cases). Five parallel groups received 1) dawn simulation (0.0003-250 lux in the pattern of May 5 at 45 degrees north latitude); 2) a dawn light pulse (13 minutes, 250 lux, with an illuminant dose of 3.25x10(3) lux-minutes matched to the simulated dawn); 3) postawakening bright light (30 minutes, 10,000 lux); 4) negative air ionization at high flow rate (93 minutes, 4.5x10(14 )ions/second); or 5) ionization at low flow rate (93 minutes, 1.7x10(11) ions/second).
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The role of genetic factors in the etiology of seasonal affective disorder and seasonality

Sher L, Goldman D, Ozaki N, Rosenthal NE.
Clinical Psychobiology Branch, National Institute of Mental Health, Bethesda, MD, USA.
J Affect Disord. 1999 Jun;53(3):203-10.

The study of the genetic basis of seasonal affective disorder (SAD), a condition where depressions in fall and winter alternate with nondepressed periods in the spring and summer, has recently received attention. The data on the genetics of seasonal affective disorders are of three types: 1.
Familiality: Studies on the prevalence of psychiatric disorders among relatives of patients with SAD suggested a familial contribution to the development of SAD; 2.
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What is this thing called "SAD"? A critique of the concept of Seasonal Affective Disorder

Hansen V, Skre I, Lund E.
Institute of Clinical Medicine, University of Tromsø, Norway.
Epidemiol Psichiatr Soc. 2008 Apr-Jun;17(2):120-7.

BACKGROUND: Seasonal Affective Disorder (SAD) is supposed to be caused by lack of daylight in winter. Yet the population of Northern Norway, living without sun for two winter months, does not spontaneously complain about depression during the dark period. 
AIMS: To summarize research bearing upon the validity of the concept of SAD.
METHOD: Review of relevant literature concerning the epidemiology of SAD and the questionnaire developed to measure it in general populations, the Seasonal Pattern Assessment Questionnaire (SPAQ).
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Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, -1438G/A

Enoch MA, Goldman D, Barnett R, Sher L, Mazzanti CM, Rosenthal NE.
Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
Mol Psychiatry. 1999 Jan;4(1):89-92.

Genes involved in serotonin metabolism are good candidates for the pathogenesis of seasonal affective disorder (SAD). A functional variant in the serotonin transporter promoter, 5-HTTLPR, has recently been shown to be associated with SAD and seasonality. The purpose of this study was to determine whether -1438G/A, a polymorphism in the 5-HT2A promoter, is associated with SAD and seasonality, and whether it has additive effects with 5-HTTLPR on seasonality. Sixty-seven individuals with SAD and 69 normal volunteers, all screened with the SCID and diagnosed according to DSM-III-R criteria, were genotyped for the -1 438G/A 5-HT2A promoter polymorphism.

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