Internet and Psychiatry

Strakowski SM, Adler CM, Cerullo MA, Eliassen JC, Lamy M, Fleck DE, Lee JH, Delbello MP.
Division of Bipolar Disorders Research, Department of Psychiatry, and the Center for Imaging Research, University of Cincinnati, Cincinnati, OH, USA
Early Interv Psychiatry. 2008 Nov;2(4):225-233.

OBJECTIVES: Impulsivity is common in bipolar disorder, especially during mania. Understanding the functional neuroanatomy of response inhibition, one component of impulsivity, might clarify the neural substrate of bipolar disorder.
METHODS: Sixteen DSM-IV first-episode, manic bipolar patients and 16 matched healthy subjects were examined during a first manic episode using fMRI while performing a response inhibition task. All subjects were studied using a 4 T Varian INOVA whole body MRI system. The response inhibition task was presented using nonferromagnetic goggles and task performance was recorded during scan acquisition. Imaging data were analyzed using AFNI.

Sher L, Carballo JJ, Grunebaum MF, Burke AK, Zalsman G, Huang YY, Mann JJ, Oquendo MA.
Division of Neuroscience, Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY, USA.
Bipolar Disord. 2006 Oct;8(5 Pt 2):543-50.

OBJECTIVES: Bipolar disorder is a severe illness that is associated with suicidal behavior. A biological predictor of highly lethal suicide attempts in patients with bipolar disorder would be valuable. We hypothesized that cerebrospinal fluid (CSF) monoamine metabolite levels are related to lethality of suicide attempts in bipolar patients and examined the relation between CSF 5-hydroxyindolacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) levels and maximum lethality of suicide attempts at baseline and during a 2-year follow up.