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Discovery of a pathway that regulates the proper sorting of many synaptic proteins

Leo Sher, M.D.

The article, “The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors” by Jeffrey N. Savas, Luís F. Ribeiro, Keimpe D. Wierda, Rebecca Wright, Laura A. DeNardo-Wilke, Heather C. Rice, Ingrid Chamma, Yi-Zhi Wang, Roland Zemla, Mathieu Lavallée-Adam, Kristel M. Vennekens, Matthew L. O’Sullivan, Joseph K. Antonios, Elizabeth A. Hall, Olivier Thoumine, Alan D. Attie, John R. Yates III,  Anirvan Ghosh,  and Joris de Wit has just been published in “Neuron” (1).

Our brain consists of billions of neurons.  Neurons can be described as morphologic and functional units of the nervous system, consisting of the nerve cell body with its dendrites and axon.

The underrepresentation of tornado disasters in post-traumatic stress disorder literature

Scott A. Laurenzo, Jess G Fiedorowicz, M.D., Ph.D.

Disasters, wars, and other devastating events have the potential to cause post-traumatic stress disorder (PTSD). This diversity of events and settings may influence study of the disease’s course. With regard to natural disasters, current research over-emphasizes the short-term effects of single events covering large areas such as hurricanes. Meanwhile, communities affected by other disasters such as tornados are underrepresented in the PTSD literature. Considering years as recent as 2004 and 2011 are some of the most active years for tornados in the United States, one might expect a large post-tornado PTSD research literature (1).

Cocaine use and its effects in human life: a review

Dinesh Sangroula, M.D., Muhammad Ovais, M.D., Fahad Waseem, M.B.B.S.

Background: Cocaine is a powerful stimulant that directly affects the brain. It is used by more than 14 million people worldwide. Cocaine accounts for about 13 % of all admissions related to drug abuse in the hospitals. Its use disorder is now a rational for the diagnosis of cocaine abuse and cocaine dependence according to the DSM –V criteria. It is one of the most prevalent public health problems worldwide and the number of users is increasing day by day. Unlike heroin and alcohol, there is no any FDA approved medication for its acute overdose or its chronic use.

The World Federation of Societies of Biological Psychiatry (WFSBP) Task Force on Men's Mental Health welcomes new Members

Leo Sher, M.D.

Timothy R. Rice has become a Co-Chair of the World Federation of Societies of Biological Psychiatry (WFSBP) Task Force on Men’s Mental Health. Timothy R. Rice was the Secretary of the WFSBP Task Force on Men’s Mental Health.

The WFSBP Task Force on Men’s Mental Health welcomes 6 new Members:

E-cigarettes risks

Manasa Enja, M.D., Kavitha Srinivasan, M.D., Lee Smith, B.A., Steven Lippmann, M.D.

Electronic cigarettes have risen in popularity in recent years. Known as e-cigarettes, they have been promoted as being safer than tobacco products and as a means for smoking cessation. Rather unregulated, they are easily available on the internet.

These battery-operated electronic nicotine-delivery devices work by vaporizing a solution containing nicotine, propylene glycol, and many other substances. Due to their recent entry into the market, scientific evidence about the effects of exposure and potential toxicity is limited. However, certain health risk issues have been raised regarding their safety, especially for younger people.

Avoiding and treating lithium neurotoxicity 

Gurpreet Singh, M.D., Pramod Kayathi, M.D., Vivek C. Shah, M.D., Steven Lippmann, M.D.

Patient education and physician awareness during lithium pharmacotherapy can usually avoid lithium neurotoxicities.  Careful prescribing with clinical monitoring facilitates safe practice. Serum lithium levels within therapeutic ranges provide evidence of appropriate treatment, and deviations from this regimen require explanatory documentation. Always consider renal, cardiac, general health status, and hydration factors while prescribing. Lithium clearance progressively declines with age and/or kidney dysfunction. Serum concentrations are standardized for assessment interpretation 12 hours after last dosing.

Walking as a protective factor against depression in geriatric-psychiatric patients

Yulin Chu, N.P.

Million years ago, walking on two legs was a key attribute to human being development that distinguished itself from animals. Since then, we have been getting many benefits from walking. Is walking also beneficial to human’s mood? Can one improve depressed mood by walking? Many evidences suggest that physical activity/walking is a protective factor against depression (Brown et al., 2012; Robertson, R., Robertson, A., Jepson, & Maxwell, 2012). Physically active people often demonstrate lower rate of depressed mood than people with sedentary lifestyle and less engagement in physical activity (Middleton & Yaffe, 2009).

The Task Force on Men's Mental Health

Leo Sher, M.D.

The World Federation of Societies of Biological Psychiatry (WFSBP) Task Force on Men’s Mental Health was founded in 2013.

Currently, the Task Force consists of the following experts:


Chair: Leo Sher (USA)

Co-Chair: Zoltan Rihmer (Hungary)

Secretary: Timothy R. Rice (USA)